Leucine

Drug profile

Key facts

Leucine is a drug catalogued in DrugCentral. DrugCentral lists 1 molecular target, including SLC7A5.

• Molecular targets: SLC7A5 (1 listed in DrugCentral).
• Molecular formula: C6H13NO2; molecular weight 131.18 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (11)

• Classical phenylketonuria
• End stage renal disease
• Heart disease
• Humoral hypercalcemia of malignancy
• Hypercalcemia
• Hypercalciuria
• Kidney disease
• Kidney stone
• Poisoning by digitalis glycoside
• Sarcoidosis
• Ventricular fibrillation

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Large neutral amino acids transporter small subunit 1	SLC7A5	unknown	IC50 4.07

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Foetal growth restriction	69.7

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Leucine is on its molecule page.

• Molecular formula: C₆H₁₃NO₂
• Molecular weight: 131.18 g/mol
• CAS number: 61-90-5
• InChIKey: ROHFNLRQFUQHCH-YFKPBYRVSA-N
• PubChem CID: 6106

CC(C)C[C@H](N)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Leucine work?

Its molecular targets in DrugCentral include SLC7A5.

What is the chemical formula of Leucine?

Leucine has the molecular formula C6H13NO2 and a molecular weight of 131.18 g/mol.

Sources

• DrugCentral drug card 1557 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL291962 — compound record and bioactivity
• PubChem CID 6106 — chemical identifiers
• DrugBank DB00149 — drug record
• FDA UNII GMW67QNF9C — substance identity
• DailyMed: FDA labels for Leucine — current prescribing information (label search)
• UniProt Q01650 (SLC7A5) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.