Macrogol

Osmotic Laxative — ALIMENTARY TRACT AND METABOLISM

Key facts

Macrogol is a drug in the Osmotic Laxative class catalogued in DrugCentral. It was first approved by the FDA in 1984. Its mechanism of action is classified as Osmotic Activity. Recorded indications include Constipation, Incomplete passage of stool, Red eye and Tear film insufficiency.

• Drug class: Osmotic Laxative.
• Mechanism of action: Osmotic Activity.
• Indications: Constipation, Incomplete passage of stool, Red eye and Tear film insufficiency.
• ATC code: A06AD15 (Osmotically acting laxatives).
• Molecular formula: (C2H4O)n.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Constipation
• Incomplete passage of stool
• Red eye
• Tear film insufficiency

Off-label uses (1)

• Keratoconjunctivitis sicca

Contraindications (45)

• Acute nephropathy
• Acute vomiting
• Angle-closure glaucoma
• Anuria
• Appendicitis
• At risk for aspiration
• Chronic heart failure
• Complete atrioventricular block
• Congenital myotonia, autosomal dominant form
• Diabetes mellitus
• Disorder of cardiovascular system
• Edema
• Eye infection
• Familial hyperkalemic periodic paralysis
• Gastric retention
• Gastrointestinal obstruction
• Gastrointestinal perforation
• Gastrointestinal ulcer
• Gastroparesis
• Hyperchloremia
• Hyperglycemia
• Hyperkalemia
• Hypertensive disorder
• Hyperthyroidism
• Hypocalcemia
• Hypokalemia
• Hyponatremia
• Hyporeninemic hypoaldosteronism
• Incontinence of feces
• Injury of eye region
• + 15 more

Mechanism & targets

• Mechanism of action (MoA): Osmotic Activity
• Established pharmacologic class: Osmotic Laxative

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2018-09-21	PMDA	—	EA Pharma Co., Ltd.
1984-07-13	FDA	—	BRAINTREE

ATC classification

ATC code	Therapeutic hierarchy
A06AD15	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR CONSTIPATION › DRUGS FOR CONSTIPATION › Osmotically acting laxatives
A06AD65	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR CONSTIPATION › DRUGS FOR CONSTIPATION › Osmotically acting laxatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Constipation	997.9
Febrile neutropenia	665.4
Macular degeneration	547.8
Pemphigus	456.4
Synovitis	452.0
Hand deformity	412.9
Contraindicated product administered	409.2
Systemic lupus erythematosus	383.5
Infective pulmonary exacerbation of cystic fibrosis	366.1
Glossodynia	358.0
Treatment failure	338.2
Rheumatoid arthritis	328.2

Chemical structure

• Molecular formula: (C₂H₄O)n
• Molecular weight: —
• CAS number: 25322-68-3
• InChIKey: —
• PubChem CID: 174

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Macrogol used for?

DrugCentral lists the following indications for Macrogol: Constipation, Incomplete passage of stool, Red eye and Tear film insufficiency.

How does Macrogol work?

Macrogol is classified as Osmotic Activity.

When was Macrogol first approved?

Macrogol was first approved by the FDA in 1984.

What drug class does Macrogol belong to?

Macrogol is in the Osmotic Laxative class.

What is the chemical formula of Macrogol?

Macrogol has the molecular formula (C2H4O)n.

Sources

• DrugCentral drug card 4253 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201478 — compound record and bioactivity
• PubChem CID 174 — chemical identifiers
• DrugBank DB09287 — drug record
• FDA UNII G2M7P15E5P — substance identity
• DailyMed: FDA labels for Macrogol — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

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