Mechlorethamine
Alkylating Drug — ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Also known as: chlormethine, mechlorethamine HCl, mechlorethamine hydrochloride, mustargen, mustine, nitrogen mustard
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Mechlorethamine is an ofp drug in the Alkylating Drug class catalogued in DrugCentral. It was first approved by the FDA in 1949. Its mechanism of action is classified as Alkylating Activity. Recorded indications include Chronic lymphoid leukemia, disease, Chronic myeloid leukemia, Hodgkin's disease and Malignant tumor of lung.
- Approval status: ofp (first approved 1949 by the FDA).
- Drug class: Alkylating Drug.
- Mechanism of action: Alkylating Activity.
- Indications: Chronic lymphoid leukemia, disease, Chronic myeloid leukemia, Hodgkin's disease, Malignant tumor of lung and Mycosis fungoides and others.
- ATC code: L01AA05 (Nitrogen mustard analogues).
- Molecular formula: C5H11Cl2N; molecular weight 156.06 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (11)
- Chronic lymphoid leukemia, disease
- Chronic myeloid leukemia
- Hodgkin's disease
- Malignant tumor of lung
- Mycosis fungoides
- Non-Hodgkin's lymphoma
- Pericardial Malignant Effusions
- Peritoneal Malignant Effusions
- Pleural Malignant Effusions
- Polycythemia vera
- Primary cutaneous T-cell lymphoma
Contraindications (13)
- Acute infectious disease
- Amyloidosis
- Anemia
- Blood coagulation disorder
- Bone marrow depression
- Breastfeeding (mother)
- Chemotherapy-Induced Hyperuricemia
- Granulocytopenic disorder
- Hyperuricemia
- Leukopenia
- Pregnancy, function
- Secondary malignant neoplasm of bone marrow
- Thrombocytopenic disorder
Mechanism & targets
| Mechanism of action (MoA) | Alkylating Activity |
|---|---|
| Established pharmacologic class | Alkylating Drug |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1949-03-15 | FDA | — | RECORDATI RARE |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
L01AA05 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › ALKYLATING AGENTS › Nitrogen mustard analogues |
Reported adverse-event signals
Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.
| MedDRA term | LLR |
|---|---|
| Application site pruritus | 967.0 |
| Application site erythema | 789.3 |
| Application site pain | 727.5 |
| Application site irritation | 408.1 |
| Application site discolouration | 355.5 |
| Skin irritation | 325.4 |
| Pruritus | 314.2 |
| Application site vesicles | 295.6 |
| Skin discolouration | 247.8 |
| Erythema | 229.7 |
| Acute myeloid leukaemia | 207.8 |
| Therapy non-responder | 197.2 |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Mechlorethamine is on its molecule page.
| Molecular formula | C5H11Cl2N |
|---|---|
| Molecular weight | 156.06 g/mol |
| CAS number | — |
| InChIKey | HAWPXGHAZFHHAD-UHFFFAOYSA-N |
| PubChem CID | 4033 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Mechlorethamine used for?
DrugCentral lists the following indications for Mechlorethamine: Chronic lymphoid leukemia, disease, Chronic myeloid leukemia, Hodgkin's disease, Malignant tumor of lung, Mycosis fungoides, Non-Hodgkin's lymphoma, Pericardial Malignant Effusions and Peritoneal Malignant Effusions and others.
How does Mechlorethamine work?
Mechlorethamine is classified as Alkylating Activity.
When was Mechlorethamine first approved?
Mechlorethamine was first approved by the FDA in 1949.
What drug class does Mechlorethamine belong to?
Mechlorethamine is in the Alkylating Drug class.
What is the chemical formula of Mechlorethamine?
Mechlorethamine has the molecular formula C5H11Cl2N and a molecular weight of 156.06 g/mol.
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Sources
- DrugCentral drug card 1647 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1201001 — compound record and bioactivity
- PubChem CID 4033 — chemical identifiers
- DrugBank DB00888 — drug record
- FDA UNII 50D9XSG0VR — substance identity
- DailyMed: FDA labels for Mechlorethamine — current prescribing information (label search)
- FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
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