Melphalan flufenamide

Alkylating Drug — ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Key facts

Melphalan flufenamide is an ofm drug in the Alkylating Drug class catalogued in DrugCentral. It was first approved by the FDA in 2021. Its mechanism of action is classified as Alkylating Activity. Recorded indications include Relapsed or refractory multiple myeloma.

• Approval status: ofm (first approved 2021 by the FDA).
• Drug class: Alkylating Drug.
• Mechanism of action: Alkylating Activity.
• Indications: Relapsed or refractory multiple myeloma.
• ATC code: L01AA10 (Nitrogen mustard analogues).
• Molecular formula: C24H30Cl2FN3O3; molecular weight 498.42 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Relapsed or refractory multiple myeloma

Contraindications (1)

• Breastfeeding (mother)

Mechanism & targets

• Mechanism of action (MoA): Alkylating Activity
• Established pharmacologic class: Alkylating Drug

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2022-08-17	EMA	—	ONCOPEPTIDES AB	Yes
2021-02-26	FDA	—	ONCOPEPTIDES AB	Yes

ATC classification

ATC code	Therapeutic hierarchy
L01AA10	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › ALKYLATING AGENTS › Nitrogen mustard analogues

Chemical structure

• Molecular formula: C₂₄H₃₀Cl₂FN₃O₃
• Molecular weight: 498.42 g/mol
• CAS number: 380449-51-4
• InChIKey: YQZNKYXGZSVEHI-VXKWHMMOSA-N
• PubChem CID: 9935639

CCOC(=O)[C@H](CC1=CC=C(C=C1)F)NC(=O)[C@H](CC2=CC=C(C=C2)N(CCCl)CCCl)N

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Melphalan flufenamide used for?

DrugCentral lists the following indications for Melphalan flufenamide: Relapsed or refractory multiple myeloma.

How does Melphalan flufenamide work?

Melphalan flufenamide is classified as Alkylating Activity.

When was Melphalan flufenamide first approved?

Melphalan flufenamide was first approved by the FDA in 2021.

What drug class does Melphalan flufenamide belong to?

Melphalan flufenamide is in the Alkylating Drug class.

What is the chemical formula of Melphalan flufenamide?

Melphalan flufenamide has the molecular formula C24H30Cl2FN3O3 and a molecular weight of 498.42 g/mol.

Sources

• DrugCentral drug card 5445 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL4297403 — compound record and bioactivity
• PubChem CID 9935639 — chemical identifiers
• DrugBank DB16627 — drug record
• FDA UNII F70C5K4786 — substance identity
• DailyMed: FDA labels for Melphalan flufenamide — current prescribing information (label search)

How this page is built: methodology · editorial policy & corrections.