Methocarbamol
Muscle Relaxant — MUSCULO-SKELETAL SYSTEM
Also known as: glycerylguaiacolate carbamate, guaiacol glyceryl ether carbamate, guaiamar carbamate, guaiphenesin carbamate
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Methocarbamol is an ofp drug in the Muscle Relaxant class catalogued in DrugCentral. It was first approved by the FDA in 1957. DrugCentral lists 1 molecular target, including CA1. Recorded indications include Muscle Spasm with Pain, Spasticity and Tetanus Adjunct Treatment.
- Approval status: ofp (first approved 1957 by the FDA).
- Drug class: Muscle Relaxant.
- Molecular targets: CA1 (1 listed in DrugCentral).
- Indications: Muscle Spasm with Pain, Spasticity and Tetanus Adjunct Treatment.
- ATC code: M03BA03 (Carbamic acid esters).
- Molecular formula: C11H15NO5; molecular weight 241.24 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (3)
- Muscle Spasm with Pain
- Spasticity
- Tetanus Adjunct Treatment
Contraindications (22)
- Acute erosive gastritis
- Acute nephropathy
- Alcoholism
- Anemia
- Anemia due to enzyme deficiency
- Breastfeeding (mother)
- Disease of liver
- Factor II deficiency
- Gastrointestinal hemorrhage
- Gastrointestinal ulcer
- Gout
- Hemophilia
- Kidney disease
- Nasal polyp
- Peptic ulcer
- Pregnancy, function
- Reye's syndrome
- Seizure disorder
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
- Vitamin K deficiency
- von Willebrand disorder
Mechanism & targets
| Established pharmacologic class | Muscle Relaxant |
|---|
Molecular targets (1)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Carbonic anhydrase 1 | CA1 | inhibitor | Ki 7.60 |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1957-07-16 | FDA | — | AUXILIUM PHARMS LLC |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
M03BA03 | MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS › Carbamic acid esters |
M03BA53 | MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS › Carbamic acid esters |
M03BA73 | MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS › Carbamic acid esters |
Reported adverse-event signals
Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.
| MedDRA term | LLR |
|---|---|
| Completed suicide | 216.2 |
| Respiratory depression | 155.4 |
| Drug dependence | 150.7 |
| Child abuse | 150.3 |
| Epidural lipomatosis | 116.6 |
| Spinal operation | 107.0 |
| Pemphigus | 98.8 |
| Synovitis | 93.2 |
| Product prescribing error | 87.8 |
| Surgery | 86.0 |
| Product dose omission issue | 84.9 |
| Back pain | 82.4 |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Methocarbamol is on its molecule page.
| Molecular formula | C11H15NO5 |
|---|---|
| Molecular weight | 241.24 g/mol |
| CAS number | 532-03-6 |
| InChIKey | GNXFOGHNGIVQEH-UHFFFAOYSA-N |
| PubChem CID | 4107 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Methocarbamol used for?
DrugCentral lists the following indications for Methocarbamol: Muscle Spasm with Pain, Spasticity and Tetanus Adjunct Treatment.
How does Methocarbamol work?
Its molecular targets in DrugCentral include CA1 (inhibitor).
When was Methocarbamol first approved?
Methocarbamol was first approved by the FDA in 1957.
What drug class does Methocarbamol belong to?
Methocarbamol is in the Muscle Relaxant class.
What is the chemical formula of Methocarbamol?
Methocarbamol has the molecular formula C11H15NO5 and a molecular weight of 241.24 g/mol.
Browse: all drugs starting with M · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 1747 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1201117 — compound record and bioactivity
- PubChem CID 4107 — chemical identifiers
- DrugBank DB00423 — drug record
- FDA UNII 125OD7737X — substance identity
- DailyMed: FDA labels for Methocarbamol — current prescribing information (label search)
- UniProt P00915 (CA1) — target protein
- FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
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