Oxandrolone

ALIMENTARY TRACT AND METABOLISM

Key facts

Oxandrolone is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1964. DrugCentral lists 1 molecular target, including AR. Recorded indications include Catabolic Process.

• Approval status: ofm (first approved 1964 by the FDA).
• Molecular targets: AR (1 listed in DrugCentral).
• Indications: Catabolic Process.
• ATC code: A14AA08 (Androstan derivatives).
• Molecular formula: C19H30O3; molecular weight 306.45 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Catabolic Process

Off-label uses (1)

• Turner syndrome

Contraindications (19)

• Arteriosclerotic vascular disease
• Benign prostatic hyperplasia
• Blood coagulation disorder
• Breast Carcinoma in Males
• Breastfeeding (mother)
• Cholestatic hepatitis
• Disease of liver
• Disorder of coronary artery
• Edema
• Heart failure
• Hypercalcemia
• Hypercholesterolemia
• Hypoalphalipoproteinemia
• Kidney disease
• Neoplasm of liver
• Neoplasm of prostate
• Nephrotic syndrome
• Peliosis hepatis
• Pregnancy, function

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Androgen receptor	AR	agonist	IC50 9.09

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1964-07-21	FDA	—	CREALTA PHARMS LLC

ATC classification

ATC code	Therapeutic hierarchy
A14AA08	ALIMENTARY TRACT AND METABOLISM › ANABOLIC AGENTS FOR SYSTEMIC USE › ANABOLIC STEROIDS › Androstan derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Testicular atrophy	80.8
Drug abuse	73.9
Cardiac death	66.3
Polycythaemia	66.1
Muscle mass	65.5
Myocardial fibrosis	52.5
Left ventricular hypertrophy	45.4
Hereditary angioedema	43.3

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Oxandrolone is on its molecule page.

• Molecular formula: C₁₉H₃₀O₃
• Molecular weight: 306.45 g/mol
• CAS number: 53-39-4
• InChIKey: QSLJIVKCVHQPLV-PEMPUTJUSA-N
• PubChem CID: 5878

C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4CC(=O)OC[C@]4(C)[C@H]3CC[C@]12C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Oxandrolone used for?

DrugCentral lists the following indications for Oxandrolone: Catabolic Process.

How does Oxandrolone work?

Its molecular targets in DrugCentral include AR (agonist).

When was Oxandrolone first approved?

Oxandrolone was first approved by the FDA in 1964.

What is the chemical formula of Oxandrolone?

Oxandrolone has the molecular formula C19H30O3 and a molecular weight of 306.45 g/mol.

Sources

• DrugCentral drug card 2011 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200436 — compound record and bioactivity
• PubChem CID 5878 — chemical identifiers
• DrugBank DB00621 — drug record
• FDA UNII 7H6TM3CT4L — substance identity
• DailyMed: FDA labels for Oxandrolone — current prescribing information (label search)
• UniProt P10275 (AR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.