Oxymetholone

ALIMENTARY TRACT AND METABOLISM

Key facts

Oxymetholone is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1972. DrugCentral lists 3 molecular targets, including Ar, ESR1 and AR. Recorded indications include Aplastic anemia, Congenital hypoplastic anemia and Hypoplastic anemia.

• Approval status: ofm (first approved 1972 by the FDA).
• Molecular targets: Ar, ESR1 and AR (3 listed in DrugCentral).
• Indications: Aplastic anemia, Congenital hypoplastic anemia and Hypoplastic anemia.
• ATC code: A14AA05 (Androstan derivatives).
• Molecular formula: C21H32O3; molecular weight 332.48 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Aplastic anemia
• Congenital hypoplastic anemia
• Hypoplastic anemia

Contraindications (22)

• Arteriosclerotic vascular disease
• Benign prostatic hyperplasia
• Blood coagulation disorder
• Breast Carcinoma in Males
• Breastfeeding (mother)
• Carcinoma of female breast
• Chronic heart failure
• Diabetes mellitus
• Disease of liver
• Disorder of coronary artery
• Edema
• Heart disease
• Hepatic failure
• Humoral hypercalcemia of malignancy
• Hypercholesterolemia
• Hypoalphalipoproteinemia
• Kidney disease
• Liver function tests abnormal
• Neoplasm of prostate
• Nephrotic syndrome
• Peliosis hepatis
• Pregnancy, function

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Androgen receptor	Ar	unknown	Ki 6.86
Estrogen receptor	ESR1	unknown	—
Androgen receptor	AR	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1972-01-18	FDA	—	MEDA PHARMS

ATC classification

ATC code	Therapeutic hierarchy
A14AA05	ALIMENTARY TRACT AND METABOLISM › ANABOLIC AGENTS FOR SYSTEMIC USE › ANABOLIC STEROIDS › Androstan derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Oxymetholone is on its molecule page.

• Molecular formula: C₂₁H₃₂O₃
• Molecular weight: 332.48 g/mol
• CAS number: 434-07-1
• InChIKey: ICMWWNHDUZJFDW-DHODBPELSA-N
• PubChem CID: 5281034

C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4CC(=O)\C(C[C@]4(C)[C@H]3CC[C@]12C)=C/O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Oxymetholone used for?

DrugCentral lists the following indications for Oxymetholone: Aplastic anemia, Congenital hypoplastic anemia and Hypoplastic anemia.

How does Oxymetholone work?

Its molecular targets in DrugCentral include Ar, ESR1 and AR (agonist).

When was Oxymetholone first approved?

Oxymetholone was first approved by the FDA in 1972.

What is the chemical formula of Oxymetholone?

Oxymetholone has the molecular formula C21H32O3 and a molecular weight of 332.48 g/mol.

Sources

• DrugCentral drug card 2033 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200585 — compound record and bioactivity
• PubChem CID 5281034 — chemical identifiers
• DrugBank DB06412 — drug record
• FDA UNII L76T0ZCA8K — substance identity
• DailyMed: FDA labels for Oxymetholone — current prescribing information (label search)
• UniProt P03372 (ESR1) — target protein
• UniProt P10275 (AR) — target protein

How this page is built: methodology · editorial policy & corrections.