Pegademase
Bovine Intestinal Adenosine Deaminase — ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Also known as: adagen, pegademase bovine
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Pegademase is a drug in the Bovine Intestinal Adenosine Deaminase class catalogued in DrugCentral. It was first approved by the FDA in 1990. Recorded indications include Adenosine deaminase deficiency.
- Drug class: Bovine Intestinal Adenosine Deaminase.
- Indications: Adenosine deaminase deficiency.
- ATC code: L03AX04 (Other immunostimulants).
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Adenosine deaminase deficiency
Mechanism & targets
| Established pharmacologic class | Bovine Intestinal Adenosine Deaminase |
|---|
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1990-03-21 | FDA | — | SIGMA TAU | Yes |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
L03AX04 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › IMMUNOSTIMULANTS › IMMUNOSTIMULANTS › Other immunostimulants |
Reported adverse-event signals
Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.
| MedDRA term | LLR |
|---|---|
| Dermatofibrosarcoma protuberans | 91.3 |
Chemical structure
| Molecular formula | — |
|---|---|
| Molecular weight | — |
| CAS number | — |
| InChIKey | — |
| PubChem CID | — |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Pegademase used for?
DrugCentral lists the following indications for Pegademase: Adenosine deaminase deficiency.
When was Pegademase first approved?
Pegademase was first approved by the FDA in 1990.
What drug class does Pegademase belong to?
Pegademase is in the Bovine Intestinal Adenosine Deaminase class.
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Sources
- DrugCentral drug card 5206 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1201514 — compound record and bioactivity
- DrugBank DB00061 — drug record
- FDA UNII HW3H7D91F6 — substance identity
- DailyMed: FDA labels for Pegademase — current prescribing information (label search)
- FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
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