Pretomanid

Antimycobacterial — ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Pretomanid is an ofp drug in the Antimycobacterial class catalogued in DrugCentral. It was first approved by the FDA in 2019. Its mechanism of action is classified as Organic Anion Transporter 3 Inhibitors. Recorded indications include Extensively drug resistant tuberculosis.

• Approval status: ofp (first approved 2019 by the FDA).
• Drug class: Antimycobacterial.
• Mechanism of action: Organic Anion Transporter 3 Inhibitors.
• Indications: Extensively drug resistant tuberculosis.
• ATC code: J04AK08 (Other drugs for treatment of tuberculosis).
• Molecular formula: C14H12F3N3O5; molecular weight 359.26 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Extensively drug resistant tuberculosis

Mechanism & targets

• Mechanism of action (MoA): Organic Anion Transporter 3 Inhibitors
• Established pharmacologic class: Antimycobacterial

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2020-07-31	EMA	—	MYLAN IRELAND LIMITED	Yes
2019-08-14	FDA	—	MYLAN IRELAND LTD	Yes

ATC classification

ATC code	Therapeutic hierarchy
J04AK08	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIMYCOBACTERIALS › DRUGS FOR TREATMENT OF TUBERCULOSIS › Other drugs for treatment of tuberculosis

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Death	193.6
Neuropathy peripheral	153.9
Anaemia	123.0
Electrocardiogram QT prolonged	83.3
Optic neuritis	63.0
Hepatotoxicity	56.5

Chemical structure

• Molecular formula: C₁₄H₁₂F₃N₃O₅
• Molecular weight: 359.26 g/mol
• CAS number: 187235-37-6
• InChIKey: ZLHZLMOSPGACSZ-NSHDSACASA-N
• PubChem CID: 456199

FC(F)(F)OC1=CC=C(CO[C@@H]2COC3=NC(=CN3C2)N(=O)=O)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Pretomanid used for?

DrugCentral lists the following indications for Pretomanid: Extensively drug resistant tuberculosis.

How does Pretomanid work?

Pretomanid is classified as Organic Anion Transporter 3 Inhibitors.

When was Pretomanid first approved?

Pretomanid was first approved by the FDA in 2019.

What drug class does Pretomanid belong to?

Pretomanid is in the Antimycobacterial class.

What is the chemical formula of Pretomanid?

Pretomanid has the molecular formula C14H12F3N3O5 and a molecular weight of 359.26 g/mol.

Sources

• DrugCentral drug card 5344 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL227875 — compound record and bioactivity
• PubChem CID 456199 — chemical identifiers
• DrugBank DB05154 — drug record
• FDA UNII 2XOI31YC4N — substance identity
• DailyMed: FDA labels for Pretomanid — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.