Ramosetron

Drug profile

Key facts

Ramosetron is a drug catalogued in DrugCentral. It was first approved by the PMDA in 1996. DrugCentral lists 1 molecular target, including HTR3A. Recorded indications include Irritable bowel syndrome with diarrhea.

• Molecular targets: HTR3A (1 listed in DrugCentral).
• Indications: Irritable bowel syndrome with diarrhea.
• Molecular formula: C17H17N3O; molecular weight 279.34 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Irritable bowel syndrome with diarrhea

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 3A	HTR3A	antagonist	Ki 10.22

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1996-07-10	PMDA	—	Astellas

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Platelet count decreased	76.5
Neutrophil count decreased	68.4
White blood cell count decreased	66.8
Pyrexia	42.8
Febrile neutropenia	39.2

Chemical structure

• Molecular formula: C₁₇H₁₇N₃O
• Molecular weight: 279.34 g/mol
• CAS number: 132036-88-5
• InChIKey: NTHPAPBPFQJABD-LLVKDONJSA-N
• PubChem CID: 108000

CN1C=C(C(=O)[C@@H]2CCC3=C(C2)NC=N3)C2=CC=CC=C12

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Ramosetron used for?

DrugCentral lists the following indications for Ramosetron: Irritable bowel syndrome with diarrhea.

How does Ramosetron work?

Its molecular targets in DrugCentral include HTR3A (antagonist).

When was Ramosetron first approved?

Ramosetron was first approved by the PMDA in 1996.

What is the chemical formula of Ramosetron?

Ramosetron has the molecular formula C17H17N3O and a molecular weight of 279.34 g/mol.

Sources

• DrugCentral drug card 2357 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1643895 — compound record and bioactivity
• PubChem CID 108000 — chemical identifiers
• DrugBank DB09290 — drug record
• FDA UNII 7ZRO0SC54Y — substance identity
• UniProt P46098 (HTR3A) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.