Rezafungin

Echinocandin Antifungal — ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Rezafungin is an onp drug in the Echinocandin Antifungal class catalogued in DrugCentral. It was first approved by the FDA in 2023. DrugCentral lists 1 molecular target, including GSC1. Recorded indications include Candidemia and Disseminated candidiasis.

• Approval status: onp (first approved 2023 by the FDA).
• Drug class: Echinocandin Antifungal.
• Molecular targets: GSC1 (1 listed in DrugCentral).
• Indications: Candidemia and Disseminated candidiasis.
• ATC code: J02AX08 (Other antimycotics for systemic use).
• Molecular formula: C63H85N8O17+; molecular weight 1226.41 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Candidemia
• Disseminated candidiasis

Mechanism & targets

• Established pharmacologic class: Echinocandin Antifungal

Molecular targets (1)

Target	Gene	Action	Activity
Beta-1,3-glucan synthase catalytic subunit 1	GSC1	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2023-03-22	FDA	—	CIDARA THERAPEUTICS, INC	Yes

ATC classification

ATC code	Therapeutic hierarchy
J02AX08	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIMYCOTICS FOR SYSTEMIC USE › ANTIMYCOTICS FOR SYSTEMIC USE › Other antimycotics for systemic use

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Off label use	116.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Rezafungin is on its molecule page.

• Molecular formula: C₆₃H₈₅N₈O₁₇+
• Molecular weight: 1226.41 g/mol
• CAS number: —
• InChIKey: LNFCWEXGZIEGJW-TXSVMFMRSA-O
• PubChem CID: 78318119

CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)N[C@H]4C[C@H]([C@H](NC(=O)[C@@H]5[C@H]([C@H](CN5C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC4=O)[C@@H](C)O)O)[C@@H]([C@H](C7=CC=C(C=C7)O)O)O)[C@@H](C)O)C)O)OCC[N+](C)(C)C)O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Rezafungin used for?

DrugCentral lists the following indications for Rezafungin: Candidemia and Disseminated candidiasis.

How does Rezafungin work?

Its molecular targets in DrugCentral include GSC1 (inhibitor).

When was Rezafungin first approved?

Rezafungin was first approved by the FDA in 2023.

What drug class does Rezafungin belong to?

Rezafungin is in the Echinocandin Antifungal class.

What is the chemical formula of Rezafungin?

Rezafungin has the molecular formula C63H85N8O17+ and a molecular weight of 1226.41 g/mol.

Sources

• DrugCentral drug card 5716 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3989928 — compound record and bioactivity
• PubChem CID 78318119 — chemical identifiers
• DrugBank DB16310 — drug record
• FDA UNII G013B5478J — substance identity
• DailyMed: FDA labels for Rezafungin — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.