Caspofungin

Echinocandin Antifungal — ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Caspofungin is an ofp drug in the Echinocandin Antifungal class catalogued in DrugCentral. It was first approved by the FDA in 2001. DrugCentral lists 4 molecular targets, including CaFKS1, GSC1 and ABCG2. Recorded indications include Candida Peritonitis, Candida Pleural Space Infection, Candidemia and Candidiasis of the esophagus.

• Approval status: ofp (first approved 2001 by the FDA).
• Drug class: Echinocandin Antifungal.
• Molecular targets: CaFKS1, GSC1, ABCG2 and 1,3-beta-glucan synthase catalytic subunit FksP (4 listed in DrugCentral).
• Indications: Candida Peritonitis, Candida Pleural Space Infection, Candidemia, Candidiasis of the esophagus and Intra-Abdominal Candida Abscess and others.
• ATC code: J02AX04 (Other antimycotics for systemic use).
• Molecular formula: C52H88N10O15; molecular weight 1093.33 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (6)

• Candida Peritonitis
• Candida Pleural Space Infection
• Candidemia
• Candidiasis of the esophagus
• Intra-Abdominal Candida Abscess
• Refractory Aspergillosis

Off-label uses (1)

• Oropharyngeal Candidiasis

Contraindications (3)

• Disease of liver
• Hypokalemia
• Liver function tests abnormal

Mechanism & targets

• Established pharmacologic class: Echinocandin Antifungal

Molecular targets (4)

Target	Gene	Action	Activity
1,3-beta-D-glucan synthase catalytic subunit	CaFKS1	unknown	IC50 9.62
Beta-1,3-glucan synthase catalytic subunit 1	GSC1	inhibitor	IC50 8.89
ATP-binding cassette sub-family G member 2	ABCG2	unknown	IC50 5.22
1,3-beta-glucan synthase catalytic subunit FksP	—	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2001-01-26	FDA	—	MERCK

ATC classification

ATC code	Therapeutic hierarchy
J02AX04	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIMYCOTICS FOR SYSTEMIC USE › ANTIMYCOTICS FOR SYSTEMIC USE › Other antimycotics for systemic use

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug ineffective	821.5
Multiple organ dysfunction syndrome	707.9
Systemic mycosis	539.2
Bronchopulmonary aspergillosis	503.4
Drug resistance	495.9
Aspergillus infection	484.7
Septic shock	481.3
Pathogen resistance	342.4
Mucormycosis	340.6
Systemic candida	333.1
Drug reaction with eosinophilia and systemic symptoms	290.5
Candida infection	289.7

Chemical structure

• Molecular formula: C₅₂H₈₈N₁₀O₁₅
• Molecular weight: 1093.33 g/mol
• CAS number: 162808-62-0
• InChIKey: JYIKNQVWKBUSNH-WVDDFWQHSA-N
• PubChem CID: 16119814

CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)C1=CC=C(O)C=C1)[C@H](O)CCN

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Caspofungin used for?

DrugCentral lists the following indications for Caspofungin: Candida Peritonitis, Candida Pleural Space Infection, Candidemia, Candidiasis of the esophagus, Intra-Abdominal Candida Abscess and Refractory Aspergillosis.

How does Caspofungin work?

Its molecular targets in DrugCentral include CaFKS1, GSC1 (inhibitor), ABCG2 and 1,3-beta-glucan synthase catalytic subunit FksP (inhibitor).

When was Caspofungin first approved?

Caspofungin was first approved by the FDA in 2001.

What drug class does Caspofungin belong to?

Caspofungin is in the Echinocandin Antifungal class.

What is the chemical formula of Caspofungin?

Caspofungin has the molecular formula C52H88N10O15 and a molecular weight of 1093.33 g/mol.

Sources

• DrugCentral drug card 2977 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1630575 — compound record and bioactivity
• PubChem CID 16119814 — chemical identifiers
• DrugBank DB00520 — drug record
• FDA UNII F0XDI6ZL63 — substance identity
• DailyMed: FDA labels for Caspofungin — current prescribing information (label search)
• UniProt Q9UNQ0 (ABCG2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.