Sivelestat

Drug profile

Key facts

Sivelestat is a drug catalogued in DrugCentral. DrugCentral lists 4 molecular targets, including Elane, ELANE and PRTN3. Recorded indications include Acute lung injury.

• Molecular targets: Elane, ELANE, PRTN3 and FAP (4 listed in DrugCentral).
• Indications: Acute lung injury.
• Molecular formula: C20H22N2O7S; molecular weight 434.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Acute lung injury

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Neutrophil elastase	Elane	unknown	IC50 6.84
Neutrophil elastase	ELANE	unknown	Ki 6.70
Myeloblastin	PRTN3	unknown	IC50 6.47
Prolyl endopeptidase FAP	FAP	unknown	Ki 6.23

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	PMDA	—	—

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Interstitial lung disease	61.7
Therapy non-responder	53.4

Chemical structure

• Molecular formula: C₂₀H₂₂N₂O₇S
• Molecular weight: 434.47 g/mol
• CAS number: —
• InChIKey: BTGNGJJLZOIYID-UHFFFAOYSA-N
• PubChem CID: 107706

CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC1=C(C=CC=C1)C(=O)NCC(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Sivelestat used for?

DrugCentral lists the following indications for Sivelestat: Acute lung injury.

How does Sivelestat work?

Its molecular targets in DrugCentral include Elane, ELANE, PRTN3 and FAP.

What is the chemical formula of Sivelestat?

Sivelestat has the molecular formula C20H22N2O7S and a molecular weight of 434.47 g/mol.

Sources

• DrugCentral drug card 2452 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3182314 — compound record and bioactivity
• PubChem CID 107706 — chemical identifiers
• DrugBank DB12863 — drug record
• FDA UNII DWI62G0P59 — substance identity
• UniProt P08246 (ELANE) — target protein
• UniProt P24158 (PRTN3) — target protein
• UniProt Q12884 (FAP) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.