Tolperisone

MUSCULO-SKELETAL SYSTEM

Key facts

Tolperisone is a drug catalogued in DrugCentral. DrugCentral lists 4 molecular targets, including SIGMAR1, ADRA2B and VCS-alpha3. Recorded indications include Spasticity.

• Molecular targets: SIGMAR1, ADRA2B, VCS-alpha3 and Crybb2 (4 listed in DrugCentral).
• Indications: Spasticity.
• ATC code: M02AX06 (Other topical products for joint and muscular pain).
• Molecular formula: C16H23NO; molecular weight 245.37 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Spasticity

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	Ki 8.25
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 6.34
SMR1-alpha3	VCS-alpha3	unknown	Ki 5.68
BetaB2-crystallin	Crybb2	unknown	IC50 5.47

ATC classification

ATC code	Therapeutic hierarchy
M02AX06	MUSCULO-SKELETAL SYSTEM › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › Other topical products for joint and muscular pain
M03BX04	MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS › Other centrally acting agents

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• Swissmedic label: CYP2D6 · Actionable PGx

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Enzyme inhibition	68.5
Respiratory alkalosis	63.1
Serotonin syndrome	56.4
Pelvic fracture	43.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Tolperisone is on its molecule page.

• Molecular formula: C₁₆H₂₃NO
• Molecular weight: 245.37 g/mol
• CAS number: 728-88-1
• InChIKey: FSKFPVLPFLJRQB-UHFFFAOYSA-N
• PubChem CID: 5511

CC(CN1CCCCC1)C(=O)C1=CC=C(C)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Tolperisone used for?

DrugCentral lists the following indications for Tolperisone: Spasticity.

How does Tolperisone work?

Its molecular targets in DrugCentral include SIGMAR1, ADRA2B, VCS-alpha3 and Crybb2.

What is the chemical formula of Tolperisone?

Tolperisone has the molecular formula C16H23NO and a molecular weight of 245.37 g/mol.

Sources

• DrugCentral drug card 2703 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1076211 — compound record and bioactivity
• PubChem CID 5511 — chemical identifiers
• DrugBank DB06264 — drug record
• FDA UNII F5EOM0LD8E — substance identity
• UniProt Q99720 (SIGMAR1) — target protein
• UniProt P18089 (ADRA2B) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.