Vamorolone

Corticosteroid — SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS

Key facts

Vamorolone is an onp drug in the Corticosteroid class catalogued in DrugCentral. It was first approved by the FDA in 2023. Its mechanism of action is classified as Corticosteroid Hormone Receptor Agonists. DrugCentral lists 2 molecular targets, including NR3C1 and KCNH2. Recorded indications include Duchenne muscular dystrophy.

• Approval status: onp (first approved 2023 by the FDA).
• Drug class: Corticosteroid.
• Mechanism of action: Corticosteroid Hormone Receptor Agonists.
• Molecular targets: NR3C1 and KCNH2 (2 listed in DrugCentral).
• Indications: Duchenne muscular dystrophy.
• ATC code: H02AB18 (Glucocorticoids).
• Molecular formula: C22H28O4; molecular weight 356.46 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Duchenne muscular dystrophy

Mechanism & targets

• Mechanism of action (MoA): Corticosteroid Hormone Receptor Agonists
• Established pharmacologic class: Corticosteroid

Molecular targets (2)

Target	Gene	Action	Activity
Glucocorticoid receptor	NR3C1	agonist	EC50 7.00
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 4.70

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2023-10-26	FDA	—	Santhera Pharmaceuticals	Yes

ATC classification

ATC code	Therapeutic hierarchy
H02AB18	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CORTICOSTEROIDS FOR SYSTEMIC USE › CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN › Glucocorticoids

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Vamorolone is on its molecule page.

• Molecular formula: C₂₂H₂₈O₄
• Molecular weight: 356.46 g/mol
• CAS number: —
• InChIKey: ZYTXTXAMMDTYDQ-DGEXFFLYSA-N
• PubChem CID: 3035000

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)CC=C1[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Vamorolone used for?

DrugCentral lists the following indications for Vamorolone: Duchenne muscular dystrophy.

How does Vamorolone work?

Vamorolone is classified as Corticosteroid Hormone Receptor Agonists; its molecular targets in DrugCentral include NR3C1 (agonist) and KCNH2.

When was Vamorolone first approved?

Vamorolone was first approved by the FDA in 2023.

What drug class does Vamorolone belong to?

Vamorolone is in the Corticosteroid class.

What is the chemical formula of Vamorolone?

Vamorolone has the molecular formula C22H28O4 and a molecular weight of 356.46 g/mol.

Sources

• DrugCentral drug card 5749 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2348780 — compound record and bioactivity
• PubChem CID 3035000 — chemical identifiers
• DrugBank DB15114 — drug record
• FDA UNII 8XP29XMB43 — substance identity
• DailyMed: FDA labels for Vamorolone — current prescribing information (label search)
• UniProt P04150 (NR3C1) — target protein
• UniProt Q12809 (KCNH2) — target protein

How this page is built: methodology · editorial policy & corrections.