N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide

C137H135ClF13N27O16S7 — CID 158277756

About N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide

N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide (PubChem CID 158277756) has the molecular formula C137H135ClF13N27O16S7 and a molecular weight of 2922.66 g/mol. Its IUPAC name is N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide.

Molecular Properties

• Compound Name: N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide
• PubChem CID: 158277756
• Molecular Formula: C137H135ClF13N27O16S7
• Molecular Weight: 2922.66 g/mol
• Exact Mass: 2919.81
• IUPAC Name: N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide
• SMILES: CC(C)(C)NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(Cl)cnc3n2C2CCC2)cc1.CC(C)(C)NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)cnc3n2C2CCC2)cc1.CC(C)(NS(=O)(=O)c1ccc(-c2c(C(N)=O)c3cc(C4CC4)cnc3n2C2CCC2)cc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(S(C)(=O)=O)cnc3n2C2CCC2)nc1)C(F)(F)F.Cc1cnc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn1)n2-c1ccncc1.NC(=O)c1c(-c2ccc(S(=O)(=O)NC3(C(F)(F)F)CC3)cc2)n(C2CCC2)c2ncc(C3CC3)cc12
• InChI: InChI=1S/C25H25F3N4O3S.C25H27F3N4O3S.C22H23ClN4O2S.C22H17F3N6O2S.C22H23FN4O2S.C21H20F3N5O4S2/c26-25(27,28)24(10-11-24)31-36(34,35)18-8-6-15(7-9-18)21-20(22(29)33)19-12-16(14-4-5-14)13-30-23(19)32(21)17-2-1-3-17;1-24(2,25(26,27)28)31-36(34,35)18-10-8-15(9-11-18)21-20(22(29)33)19-12-16(14-6-7-14)13-30-23(19)32(21)17-4-3-5-17;1-22(2,3)26-30(28,29)17-9-7-14(8-10-17)20-19(12-24)18-11-15(23)13-25-21(18)27(20)16-5-4-6-16;1-13-9-17-18(10-26)20(31(21(17)29-11-13)15-5-7-27-8-6-15)19-4-3-16(12-28-19)34(32,33)30-14(2)22(23,24)25;1-22(2,3)26-30(28,29)17-9-7-14(8-10-17)20-19(12-24)18-11-15(23)13-25-21(18)27(20)16-5-4-6-16;1-12(21(22,23)24)28-35(32,33)14-6-7-18(26-10-14)19-17(9-25)16-8-15(34(2,30)31)11-27-20(16)29(19)13-4-3-5-13/h6-9,12-14,17,31H,1-5,10-11H2,(H2,29,33);8-14,17,31H,3-7H2,1-2H3,(H2,29,33);7-11,13,16,26H,4-6H2,1-3H3;3-9,11-12,14,30H,1-2H3;7-11,13,16,26H,4-6H2,1-3H3;6-8,10-13,28H,3-5H2,1-2H3/t;;;14-;;12-/m...0.0/s1
• InChIKey: GJVAFWHZOWJGLG-WDRZZXJYSA-N
• XLogP: 26.57
• TPSA: 638.09 Ų
• H-Bond Donors: 8
• H-Bond Acceptors: 35
• Rotatable Bonds: 33
• Heavy Atoms: 201
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2922.66
LogP ≤ 5	26.57
H-Bond Donors ≤ 5	8
H-Bond Acceptors ≤ 10	35

Frequently Asked Questions

What is the IUPAC name of N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide?

The IUPAC name of N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide (CID 158277756) is N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide.

What is the SMILES notation for N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide?

The canonical SMILES for N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide is CC(C)(C)NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(Cl)cnc3n2C2CCC2)cc1.CC(C)(C)NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)cnc3n2C2CCC2)cc1.CC(C)(NS(=O)(=O)c1ccc(-c2c(C(N)=O)c3cc(C4CC4)cnc3n2C2CCC2)cc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(S(C)(=O)=O)cnc3n2C2CCC2)nc1)C(F)(F)F.Cc1cnc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn1)n2-c1ccncc1.NC(=O)c1c(-c2ccc(S(=O)(=O)NC3(C(F)(F)F)CC3)cc2)n(C2CCC2)c2ncc(C3CC3)cc12.

What is the InChIKey of N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide?

The InChIKey is GJVAFWHZOWJGLG-WDRZZXJYSA-N. The full InChI is InChI=1S/C25H25F3N4O3S.C25H27F3N4O3S.C22H23ClN4O2S.C22H17F3N6O2S.C22H23FN4O2S.C21H20F3N5O4S2/c26-25(27,28)24(10-11-24)31-36(34,35)18-8-6-15(7-9-18)21-20(22(29)33)19-12-16(14-4-5-14)13-30-23(19)32(21)17-2-1-3-17;1-24(2,25(26,27)28)31-36(34,35)18-10-8-15(9-11-18)21-20(22(29)33)19-12-16(14-6-7-14)13-30-23(19)32(21)17-4-3-5-17;1-22(2,3)26-30(28,29)17-9-7-14(8-10-17)20-19(12-24)18-11-15(23)13-25-21(18)27(20)16-5-4-6-16;1-13-9-17-18(10-26)20(31(21(17)29-11-13)15-5-7-27-8-6-15)19-4-3-16(12-28-19)34(32,33)30-14(2)22(23,24)25;1-22(2,3)26-30(28,29)17-9-7-14(8-10-17)20-19(12-24)18-11-15(23)13-25-21(18)27(20)16-5-4-6-16;1-12(21(22,23)24)28-35(32,33)14-6-7-18(26-10-14)19-17(9-25)16-8-15(34(2,30)31)11-27-20(16)29(19)13-4-3-5-13/h6-9,12-14,17,31H,1-5,10-11H2,(H2,29,33);8-14,17,31H,3-7H2,1-2H3,(H2,29,33);7-11,13,16,26H,4-6H2,1-3H3;3-9,11-12,14,30H,1-2H3;7-11,13,16,26H,4-6H2,1-3H3;6-8,10-13,28H,3-5H2,1-2H3/t;;;14-;;12-/m...0.0/s1.

What are the key properties of N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide?

N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide has a molecular weight of 2922.66 g/mol, XLogP of 26.57, 33 rotatable bonds, 8 hydrogen bond donors, and 35 hydrogen bond acceptors.

Where does this data come from?

All data for N-tert-butyl-4-(5-chloro-3-cyano-1-cyclobutylpyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;N-tert-butyl-4-(3-cyano-1-cyclobutyl-5-fluoropyrrolo[2,3-b]pyridin-2-yl)benzenesulfonamide;6-(3-cyano-1-cyclobutyl-5-methylsulfonylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-5-methyl-1-pyridin-4-ylpyrrolo[2,3-b]pyridin-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;1-cyclobutyl-5-cyclopropyl-2-[4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide;1-cyclobutyl-5-cyclopropyl-2-[4-[(1,1,1-trifluoro-2-methylpropan-2-yl)sulfamoyl]phenyl]pyrrolo[2,3-b]pyridine-3-carboxamide is sourced from PubChem (CID 158277756), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).