N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide

C140H186F12N28O8S5 — CID 158374619

About N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide

N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide (PubChem CID 158374619) has the molecular formula C140H186F12N28O8S5 and a molecular weight of 2777.53 g/mol. Its IUPAC name is N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide.

Molecular Properties

• Compound Name: N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide
• PubChem CID: 158374619
• Molecular Formula: C140H186F12N28O8S5
• Molecular Weight: 2777.53 g/mol
• Exact Mass: 2775.34
• IUPAC Name: N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide
• SMILES: CCc1nc(NC2CCN(Cc3ccc4c(cc(C)n4C(C)C(C)N4CCN(S(C)(=O)=O)CC4)c3C)CC2)c2cc(CC(F)(F)F)sc2n1.CCc1nc(NC2CCN(Cc3ccc4c(cc(C)n4C[C@H](C)N4CCOC(C(=O)N(C)C)C4)c3C)CC2)c2cc(CC(F)(F)F)sc2n1.CCc1nc(NC2CCN(Cc3ccc4c(cc(C)n4C[C@H](C)N4CCOC(C(=O)NC)C4)c3C)CC2)c2cc(CC(F)(F)F)sc2n1.CCc1nc(NC2CCN(Cc3ccc4c(cc(C)n4C[C@H](C)N4CCOC(C(N)=O)C4)c3C)CC2)c2cc(CC(F)(F)F)sc2n1
• InChI: InChI=1S/C36H48F3N7O2S.C35H48F3N7O2S2.C35H46F3N7O2S.C34H44F3N7O2S/c1-7-32-41-33(29-17-27(18-36(37,38)39)49-34(29)42-32)40-26-10-12-44(13-11-26)20-25-8-9-30-28(24(25)4)16-22(2)46(30)19-23(3)45-14-15-48-31(21-45)35(47)43(5)6;1-7-32-40-33(30-19-28(20-35(36,37)38)48-34(30)41-32)39-27-10-12-42(13-11-27)21-26-8-9-31-29(23(26)3)18-22(2)45(31)25(5)24(4)43-14-16-44(17-15-43)49(6,46)47;1-6-31-41-32(28-16-26(17-35(36,37)38)48-34(28)42-31)40-25-9-11-43(12-10-25)19-24-7-8-29-27(23(24)4)15-21(2)45(29)18-22(3)44-13-14-47-30(20-44)33(46)39-5;1-5-30-40-32(27-15-25(16-34(35,36)37)47-33(27)41-30)39-24-8-10-42(11-9-24)18-23-6-7-28-26(22(23)4)14-20(2)44(28)17-21(3)43-12-13-46-29(19-43)31(38)45/h8-9,16-17,23,26,31H,7,10-15,18-21H2,1-6H3,(H,40,41,42);8-9,18-19,24-25,27H,7,10-17,20-21H2,1-6H3,(H,39,40,41);7-8,15-16,22,25,30H,6,9-14,17-20H2,1-5H3,(H,39,46)(H,40,41,42);6-7,14-15,21,24,29H,5,8-13,16-19H2,1-4H3,(H2,38,45)(H,39,40,41)/t23-,31?;;22-,30?;21-,29?/m0.00/s1
• InChIKey: GVAQBVWWLAMZML-CLXHWOPKSA-N
• XLogP: 24.14
• TPSA: 354.45 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 36
• Rotatable Bonds: 40
• Heavy Atoms: 193
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2777.53
LogP ≤ 5	24.14
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	36

Frequently Asked Questions

What is the IUPAC name of N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide?

The IUPAC name of N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide (CID 158374619) is N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide.

What is the SMILES notation for N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide?

The canonical SMILES for N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide is CCc1nc(NC2CCN(Cc3ccc4c(cc(C)n4C(C)C(C)N4CCN(S(C)(=O)=O)CC4)c3C)CC2)c2cc(CC(F)(F)F)sc2n1.CCc1nc(NC2CCN(Cc3ccc4c(cc(C)n4C[C@H](C)N4CCOC(C(=O)N(C)C)C4)c3C)CC2)c2cc(CC(F)(F)F)sc2n1.CCc1nc(NC2CCN(Cc3ccc4c(cc(C)n4C[C@H](C)N4CCOC(C(=O)NC)C4)c3C)CC2)c2cc(CC(F)(F)F)sc2n1.CCc1nc(NC2CCN(Cc3ccc4c(cc(C)n4C[C@H](C)N4CCOC(C(N)=O)C4)c3C)CC2)c2cc(CC(F)(F)F)sc2n1.

What is the InChIKey of N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide?

The InChIKey is GVAQBVWWLAMZML-CLXHWOPKSA-N. The full InChI is InChI=1S/C36H48F3N7O2S.C35H48F3N7O2S2.C35H46F3N7O2S.C34H44F3N7O2S/c1-7-32-41-33(29-17-27(18-36(37,38)39)49-34(29)42-32)40-26-10-12-44(13-11-26)20-25-8-9-30-28(24(25)4)16-22(2)46(30)19-23(3)45-14-15-48-31(21-45)35(47)43(5)6;1-7-32-40-33(30-19-28(20-35(36,37)38)48-34(30)41-32)39-27-10-12-42(13-11-27)21-26-8-9-31-29(23(26)3)18-22(2)45(31)25(5)24(4)43-14-16-44(17-15-43)49(6,46)47;1-6-31-41-32(28-16-26(17-35(36,37)38)48-34(28)42-31)40-25-9-11-43(12-10-25)19-24-7-8-29-27(23(24)4)15-21(2)45(29)18-22(3)44-13-14-47-30(20-44)33(46)39-5;1-5-30-40-32(27-15-25(16-34(35,36)37)47-33(27)41-30)39-24-8-10-42(11-9-24)18-23-6-7-28-26(22(23)4)14-20(2)44(28)17-21(3)43-12-13-46-29(19-43)31(38)45/h8-9,16-17,23,26,31H,7,10-15,18-21H2,1-6H3,(H,40,41,42);8-9,18-19,24-25,27H,7,10-17,20-21H2,1-6H3,(H,39,40,41);7-8,15-16,22,25,30H,6,9-14,17-20H2,1-5H3,(H,39,46)(H,40,41,42);6-7,14-15,21,24,29H,5,8-13,16-19H2,1-4H3,(H2,38,45)(H,39,40,41)/t23-,31?;;22-,30?;21-,29?/m0.00/s1.

What are the key properties of N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide?

N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide has a molecular weight of 2777.53 g/mol, XLogP of 24.14, 40 rotatable bonds, 6 hydrogen bond donors, and 36 hydrogen bond acceptors.

Where does this data come from?

All data for N-[1-[[2,4-dimethyl-1-[3-(4-methylsulfonylpiperazin-1-yl)butan-2-yl]indol-5-yl]methyl]piperidin-4-yl]-2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-amine;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N,N-dimethylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]-N-methylmorpholine-2-carboxamide;4-[(2S)-1-[5-[[4-[[2-ethyl-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-2,4-dimethylindol-1-yl]propan-2-yl]morpholine-2-carboxamide is sourced from PubChem (CID 158374619), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).