N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine

C85H51F23N26O3S4 — CID 161024291

About N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine

N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine (PubChem CID 161024291) has the molecular formula C85H51F23N26O3S4 and a molecular weight of 2049.74 g/mol. Its IUPAC name is N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine.

Molecular Properties

• Compound Name: N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine
• PubChem CID: 161024291
• Molecular Formula: C85H51F23N26O3S4
• Molecular Weight: 2049.74 g/mol
• Exact Mass: 2048.32
• IUPAC Name: N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine
• SMILES: COc1ccc(Nc2cncc(-c3c(C(F)(F)F)nc4sccn34)n2)cc1.FC(F)(F)Oc1ccc(Nc2cncc(-c3c(C(F)(F)F)nc4sccn34)n2)cc1.FC(F)(F)c1ccc(Nc2cncc(-n3c(C(F)(F)F)nc4ncccc43)n2)cc1.FC(F)(F)c1nc2sccn2c1-c1cncc(Nc2ccccc2)n1.FC(F)Oc1ccc(Nc2cncc(-c3c(C(F)(F)F)nc4sccn34)n2)cc1
• InChI: InChI=1S/C18H10F6N6.C17H9F6N5OS.C17H10F5N5OS.C17H12F3N5OS.C16H10F3N5S/c19-17(20,21)10-3-5-11(6-4-10)27-13-8-25-9-14(28-13)30-12-2-1-7-26-15(12)29-16(30)18(22,23)24;18-16(19,20)14-13(28-5-6-30-15(28)27-14)11-7-24-8-12(26-11)25-9-1-3-10(4-2-9)29-17(21,22)23;18-15(19)28-10-3-1-9(2-4-10)24-12-8-23-7-11(25-12)13-14(17(20,21)22)26-16-27(13)5-6-29-16;1-26-11-4-2-10(3-5-11)22-13-9-21-8-12(23-13)14-15(17(18,19)20)24-16-25(14)6-7-27-16;17-16(18,19)14-13(24-6-7-25-15(24)23-14)11-8-20-9-12(22-11)21-10-4-2-1-3-5-10/h1-9H,(H,27,28);1-8H,(H,25,26);1-8,15H,(H,24,25);2-9H,1H3,(H,22,23);1-9H,(H,21,22)
• InChIKey: TYTWQXFGYRLRSZ-UHFFFAOYSA-N
• XLogP: 24.96
• TPSA: 316.65 Ų
• H-Bond Donors: 5
• H-Bond Acceptors: 33
• Rotatable Bonds: 19
• Heavy Atoms: 141
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	2049.74
LogP ≤ 5	24.96
H-Bond Donors ≤ 5	5
H-Bond Acceptors ≤ 10	33

Frequently Asked Questions

What is the IUPAC name of N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine?

The IUPAC name of N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine (CID 161024291) is N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine.

What is the SMILES notation for N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine?

The canonical SMILES for N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine is COc1ccc(Nc2cncc(-c3c(C(F)(F)F)nc4sccn34)n2)cc1.FC(F)(F)Oc1ccc(Nc2cncc(-c3c(C(F)(F)F)nc4sccn34)n2)cc1.FC(F)(F)c1ccc(Nc2cncc(-n3c(C(F)(F)F)nc4ncccc43)n2)cc1.FC(F)(F)c1nc2sccn2c1-c1cncc(Nc2ccccc2)n1.FC(F)Oc1ccc(Nc2cncc(-c3c(C(F)(F)F)nc4sccn34)n2)cc1.

What is the InChIKey of N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine?

The InChIKey is TYTWQXFGYRLRSZ-UHFFFAOYSA-N. The full InChI is InChI=1S/C18H10F6N6.C17H9F6N5OS.C17H10F5N5OS.C17H12F3N5OS.C16H10F3N5S/c19-17(20,21)10-3-5-11(6-4-10)27-13-8-25-9-14(28-13)30-12-2-1-7-26-15(12)29-16(30)18(22,23)24;18-16(19,20)14-13(28-5-6-30-15(28)27-14)11-7-24-8-12(26-11)25-9-1-3-10(4-2-9)29-17(21,22)23;18-15(19)28-10-3-1-9(2-4-10)24-12-8-23-7-11(25-12)13-14(17(20,21)22)26-16-27(13)5-6-29-16;1-26-11-4-2-10(3-5-11)22-13-9-21-8-12(23-13)14-15(17(18,19)20)24-16-25(14)6-7-27-16;17-16(18,19)14-13(24-6-7-25-15(24)23-14)11-8-20-9-12(22-11)21-10-4-2-1-3-5-10/h1-9H,(H,27,28);1-8H,(H,25,26);1-8,15H,(H,24,25);2-9H,1H3,(H,22,23);1-9H,(H,21,22).

What are the key properties of N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine?

N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine has a molecular weight of 2049.74 g/mol, XLogP of 24.96, 19 rotatable bonds, 5 hydrogen bond donors, and 33 hydrogen bond acceptors.

Where does this data come from?

All data for N-[4-(difluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-(4-methoxyphenyl)-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-phenyl-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;N-[4-(trifluoromethoxy)phenyl]-6-[6-(trifluoromethyl)imidazo[2,1-b][1,3]thiazol-5-yl]pyrazin-2-amine;6-[2-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine is sourced from PubChem (CID 161024291), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).