About Carbonic anhydrase 12
Carbonic anhydrase 12 (CA12) is a protein
from Homo sapiens identified by UniProt accession
O43570, 354 residues long.
MolForge cross-references it against 0 known binders and
163 disease associations.
Target properties
| Protein name | Carbonic anhydrase 12 |
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| UniProt accession | O43570 |
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| Gene | CA12 |
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| Organism | Homo sapiens |
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| Length | 354 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (163)
Diseases linked to this target (Open Targets).
- isolated hyperchlorhidrosis · score 0.65
- glaucoma · score 0.61
- altitude sickness · score 0.60
- angle-closure glaucoma · score 0.59
- edema · score 0.59
- Seizure · score 0.59
- heart failure · score 0.57
- chronic obstructive pulmonary disease · score 0.57
- obstructive sleep apnea · score 0.54
- epilepsy · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O43570-F1 | alphafold | PREDICTED | 87.80 | — |
Amino-acid sequence (354 residues)
MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QVQVCTAAGL SLGIILSLAL AGILGICIVV VVSIWLFRRK SIKKGDNKGV IYKPATKMET EAHA
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