About Carbonic anhydrase 3
Carbonic anhydrase 3 (CA3) is a protein
from Homo sapiens identified by UniProt accession
P07451, 260 residues long.
MolForge cross-references it against 0 known binders and
153 disease associations.
Target properties
| Protein name | Carbonic anhydrase 3 |
|---|
| UniProt accession | P07451 |
|---|
| Gene | CA3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 260 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (153)
Diseases linked to this target (Open Targets).
- epilepsy · score 0.44
- mean corpuscular hemoglobin concentration · score 0.37
- mean corpuscular volume · score 0.33
- blood protein measurement · score 0.29
- vital capacity · score 0.29
- reticulocyte count · score 0.26
- neurodegenerative disease · score 0.24
- reticulocyte measurement · score 0.23
- grip strength measurement · score 0.22
- Immature Reticulocyte Fraction Measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P07451-F1 | alphafold | PREDICTED | 97.95 | — |
Amino-acid sequence (260 residues)
MAKEWGYASH NGPDHWHELF PNAKGENQSP VELHTKDIRH DPSLQPWSVS YDGGSAKTIL NNGKTCRVVF DDTYDRSMLR GGPLPGPYRL RQFHLHWGSS DDHGSEHTVD GVKYAAELHL VHWNPKYNTF KEALKQRDGI AVIGIFLKIG HENGEFQIFL DALDKIKTKG KEAPFTKFDP SCLFPACRDY WTYQGSFTTP PCEECIVWLL LKEPMTVSSD QMAKLRSLLS SAENEPPVPL VSNWRPPQPI NNRVVRASFK
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