Indoleamine 2,3-dioxygenase 1 (IDO1)

About Indoleamine 2,3-dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1) is a protein from Homo sapiens identified by UniProt accession P14902, 403 residues long. MolForge cross-references it against 0 known binders and 924 disease associations.

Target properties

Protein name	Indoleamine 2,3-dioxygenase 1
UniProt accession	P14902
Gene	IDO1
Organism	Homo sapiens
Length	403 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (13)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (924)

Diseases linked to this target (Open Targets).

melanoma · score 0.36
head and neck malignant neoplasia · score 0.36
lung cancer · score 0.34
urogenital neoplasm · score 0.32
neoplasm · score 0.31
non-small cell lung carcinoma · score 0.30
renal cell carcinoma · score 0.28
skin cancer · score 0.26
inflammatory bowel disease · score 0.16
cancer · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14902-F1	alphafold	PREDICTED	93.08	—

Amino-acid sequence (403 residues)

MAHAMENSWT ISKEYHIDEE VGFALPNPQE NLPDFYNDWM FIAKHLPDLI ESGQLRERVE KLNMLSIDHL TDHKSQRLAR LVLGCITMAY VWGKGHGDVR KVLPRNIAVP YCQLSKKLEL PPILVYADCV LANWKKKDPN KPLTYENMDV LFSFRDGDCS KGFFLVSLLV EIAAASAIKV IPTVFKAMQM QERDTLLKAL LEIASCLEKA LQVFHQIHDH VNPKAFFSVL RIYLSGWKGN PQLSDGLVYE GFWEDPKEFA GGSAGQSSVF QCFDVLLGIQ QTAGGGHAAQ FLQDMRRYMP PAHRNFLCSL ESNPSVREFV LSKGDAGLRE AYDACVKALV SLRSYHLQIV TKYILIPASQ QPKENKTSED PSKLEAKGTG GTDLMNFLKT VRSTTEKSLL KEG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards