Oxiconazole

Azole Antifungal — DERMATOLOGICALS

Key facts

Oxiconazole is an ofp drug in the Azole Antifungal class catalogued in DrugCentral. It was first approved by the FDA in 1988. DrugCentral lists 26 molecular targets, including CYP2C19, CYP3A4 and ADORA3. Recorded indications include Pityriasis versicolor, Tinea corporis, Tinea cruris and Tinea pedis.

• Approval status: ofp (first approved 1988 by the FDA).
• Drug class: Azole Antifungal.
• Molecular targets: CYP2C19, CYP3A4, ADORA3 and SLC6A4 (26 listed in DrugCentral).
• Indications: Pityriasis versicolor, Tinea corporis, Tinea cruris and Tinea pedis.
• ATC code: D01AC11 (Imidazole and triazole derivatives).
• Molecular formula: C18H13Cl4N3O; molecular weight 429.12 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Pityriasis versicolor
• Tinea corporis
• Tinea cruris
• Tinea pedis

Contraindications (1)

• Skin irritation

Mechanism & targets

• Established pharmacologic class: Azole Antifungal

Molecular targets (26)

Target	Gene	Action	Activity
Cytochrome P450 2C19	CYP2C19	unknown	IC50 7.40
Cytochrome P450 3A4	CYP3A4	unknown	IC50 7.05
Adenosine receptor A3	ADORA3	unknown	Ki 6.45
Sodium-dependent serotonin transporter	SLC6A4	unknown	Ki 6.37
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 6.22
Thromboxane-A synthase	TBXAS1	unknown	IC50 6.21
D(3) dopamine receptor	DRD3	unknown	Ki 6.17
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 6.02
Cytochrome P450 2D6	CYP2D6	unknown	IC50 6.00
Substance-K receptor	TACR2	unknown	Ki 5.97
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 5.94
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 5.92
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 5.82
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 5.78
Delta-type opioid receptor	OPRD1	unknown	Ki 5.73
Sodium-dependent noradrenaline transporter	SLC6A2	unknown	Ki 5.72
D(1A) dopamine receptor	DRD1	unknown	Ki 5.68
Sodium-dependent dopamine transporter	SLC6A3	unknown	Ki 5.68
5-hydroxytryptamine receptor 2B	HTR2B	unknown	Ki 5.53
Cytochrome P450 2C9	CYP2C9	unknown	IC50 5.52

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1988-12-30	FDA	—	FOUGERA PHARMS

ATC classification

ATC code	Therapeutic hierarchy
D01AC11	DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Imidazole and triazole derivatives
G01AF17	GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Imidazole derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Oxiconazole is on its molecule page.

• Molecular formula: C₁₈H₁₃Cl₄N₃O
• Molecular weight: 429.12 g/mol
• CAS number: 64211-45-6
• InChIKey: QRJJEGAJXVEBNE-HKOYGPOVSA-N
• PubChem CID: 5353853

ClC1=CC(Cl)=C(CO\N=C(/CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Oxiconazole used for?

DrugCentral lists the following indications for Oxiconazole: Pityriasis versicolor, Tinea corporis, Tinea cruris and Tinea pedis.

How does Oxiconazole work?

Its molecular targets in DrugCentral include CYP2C19, CYP3A4, ADORA3 and SLC6A4.

When was Oxiconazole first approved?

Oxiconazole was first approved by the FDA in 1988.

What drug class does Oxiconazole belong to?

Oxiconazole is in the Azole Antifungal class.

What is the chemical formula of Oxiconazole?

Oxiconazole has the molecular formula C18H13Cl4N3O and a molecular weight of 429.12 g/mol.

Sources

• DrugCentral drug card 3408 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200836 — compound record and bioactivity
• PubChem CID 5353853 — chemical identifiers
• DrugBank DB00239 — drug record
• FDA UNII C668Q9I33J — substance identity
• DailyMed: FDA labels for Oxiconazole — current prescribing information (label search)
• UniProt P33261 (CYP2C19) — target protein
• UniProt P08684 (CYP3A4) — target protein
• UniProt P0DMS8 (ADORA3) — target protein
• UniProt P31645 (SLC6A4) — target protein
• UniProt P18825 (ADRA2C) — target protein
• UniProt P24557 (TBXAS1) — target protein

How this page is built: methodology · editorial policy & corrections.