Carbonic anhydrase 6 (CA6)

About Carbonic anhydrase 6

Carbonic anhydrase 6 (CA6) is a protein from Homo sapiens identified by UniProt accession P23280, 308 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.

Target properties

Protein name	Carbonic anhydrase 6
UniProt accession	P23280
Gene	CA6
Organism	Homo sapiens
Length	308 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (143)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.46
epilepsy · score 0.44
carbonic anhydrase 6 measurement · score 0.39
protein measurement · score 0.31
dental caries · score 0.10
obstructive sleep apnea · score 0.07
leukocyte count · score 0.05
inflammatory bowel disease · score 0.05
severe combined immunodeficiency due to DCLRE1C deficiency · score 0.04
Kimura disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23280-F1	alphafold	PREDICTED	89.19	—

Amino-acid sequence (308 residues)

MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI NLQRTKVRYN PSLKGLNMTG YETQAGEFPM VNNGHTVQIS LPSTMRMTVA DGTVYIAQQM HFHWGGASSE ISGSEHTVDG IRHVIEIHIV HYNSKYKSYD IAQDAPDGLA VLAAFVEVKN YPENTYYSNF ISHLANIKYP GQRTTLTGLD VQDMLPRNLQ HYYTYHGSLT TPPCTENVHW FVLADFVKLS RTQVWKLENS LLDHRNKTIH NDYRRTQPLN HRVVESNFPN QEYTLGSEFQ FYLHKIEEIL DYLRRALN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards