About Nuclear receptor subfamily 1 group I member 3
Nuclear receptor subfamily 1 group I member 3 (NR1I3) is a protein
from Homo sapiens identified by UniProt accession
Q14994, 352 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | Nuclear receptor subfamily 1 group I member 3 |
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| UniProt accession | Q14994 |
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| Gene | NR1I3 |
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| Organism | Homo sapiens |
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| Length | 352 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (13)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (108)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.47
- neurodegenerative disease · score 0.27
- Red cell distribution width · score 0.26
- serum gamma-glutamyl transferase measurement · score 0.23
- Kleefstra syndrome 1 · score 0.11
- blood metabolite measurement · score 0.09
- MODY · score 0.08
- hepatocellular carcinoma · score 0.08
- platelet component distribution width · score 0.06
- mean platelet volume · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14994-F1 | alphafold | PREDICTED | 90.81 | — |
Amino-acid sequence (352 residues)
MASREDELRN CVVCGDQATG YHFNALTCEG CKGFFRRTVS KSIGPTCPFA GSCEVSKTQR RHCPACRLQK CLDAGMRKDM ILSAEALALR RAKQAQRRAQ QTPVQLSKEQ EELIRTLLGA HTRHMGTMFE QFVQFRPPAH LFIHHQPLPT LAPVLPLVTH FADINTFMVL QVIKFTKDLP VFRSLPIEDQ ISLLKGAAVE ICHIVLNTTF CLQTQNFLCG PLRYTIEDGA RVSPTVGFQV EFLELLFHFH GTLRKLQLQE PEYVLLAAMA LFSPDRPGVT QRDEIDQLQE EMALTLQSYI KGQQRRPRDR FLYAKLLGLL AELRSINEAY GYQIQHIQGL SAMMPLLQEI CS
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