Temazepam

Benzodiazepine — NERVOUS SYSTEM

Key facts

Temazepam is an ofp drug in the Benzodiazepine class catalogued in DrugCentral. It was first approved by the FDA in 1981. DrugCentral lists 2 molecular targets, including NR1I3 and GABRA1|GABRG2|GABRB2. Recorded indications include Insomnia.

• Approval status: ofp (first approved 1981 by the FDA).
• Drug class: Benzodiazepine.
• Molecular targets: NR1I3 and GABRA1|GABRG2|GABRB2 (2 listed in DrugCentral).
• Indications: Insomnia.
• ATC code: N05CD07 (Benzodiazepine derivatives).
• Molecular formula: C16H13ClN2O2; molecular weight 300.74 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Insomnia

Contraindications (13)

• Alcohol intoxication
• Chronic lung disease
• Depressive disorder
• Disease of liver
• Hypoalbuminemia
• Kidney disease
• Memory impairment
• Pregnancy, function
• Severe chronic obstructive pulmonary disease
• Sleep apnea
• Sleep automatism
• Substance abuse
• Suicidal thoughts

Mechanism & targets

• Established pharmacologic class: Benzodiazepine

Molecular targets (2)

Target	Gene	Action	Activity
Nuclear receptor subfamily 1 group I member 3	NR1I3	unknown	—
GABA-A receptor alpha-1/beta-2/gamma-2	GABRA1|GABRG2|GABRB2	positive allosteric modulator	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1981-02-27	FDA	—	MALLINCKRODT INC

ATC classification

ATC code	Therapeutic hierarchy
N05CD07	NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Benzodiazepine derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Toxicity to various agents	1573.4
Completed suicide	1242.2
Food allergy	805.0
Overdose	761.7
Temperature regulation disorder	737.4
Immunodeficiency	611.4
Drug abuse	551.9
Hyperhidrosis	436.7
Rash erythematous	369.6
Foetal death	359.9
Coeliac disease	344.7
Poisoning	330.3

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Temazepam is on its molecule page.

• Molecular formula: C₁₆H₁₃ClN₂O₂
• Molecular weight: 300.74 g/mol
• CAS number: 846-50-4
• InChIKey: SEQDDYPDSLOBDC-UHFFFAOYSA-N
• PubChem CID: 5391

CN1C2=CC=C(Cl)C=C2C(=NC(O)C1=O)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Temazepam used for?

DrugCentral lists the following indications for Temazepam: Insomnia.

How does Temazepam work?

Its molecular targets in DrugCentral include NR1I3 and GABRA1|GABRG2|GABRB2 (positive allosteric modulator).

When was Temazepam first approved?

Temazepam was first approved by the FDA in 1981.

What drug class does Temazepam belong to?

Temazepam is in the Benzodiazepine class.

What is the chemical formula of Temazepam?

Temazepam has the molecular formula C16H13ClN2O2 and a molecular weight of 300.74 g/mol.

Sources

• DrugCentral drug card 2585 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL967 — compound record and bioactivity
• PubChem CID 5391 — chemical identifiers
• DrugBank DB00231 — drug record
• FDA UNII CHB1QD2QSS — substance identity
• DailyMed: FDA labels for Temazepam — current prescribing information (label search)
• UniProt Q14994 (NR1I3) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.