Survival motor neuron protein (SMN1)
Homo sapiens — UniProt Q16637
Data last refreshed: (UniProt release unknown)
Key facts
Survival motor neuron protein (SMN1) is a protein from Homo sapiens identified by UniProt accession Q16637, 294 residues long. MolForge cross-references it against 1 known binders and 1,032 disease associations.
- UniProt accession: Q16637; gene symbol SMN1.
- Organism: Homo sapiens.
- Length: 294 amino acids.
- Approved drugs acting on it (DrugCentral): Nusinersen.
- Top disease associations (Open Targets): Proximal spinal muscular atrophy type 3, spinal muscular atrophy, type III and spinal muscular atrophy, type 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Survival motor neuron protein |
|---|---|
| UniProt accession | Q16637 |
| Gene | SMN1 |
| Organism | Homo sapiens |
| Length | 294 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (1032)
Diseases linked to this target (Open Targets).
- Proximal spinal muscular atrophy type 3 · score 0.80
- spinal muscular atrophy, type III · score 0.79
- spinal muscular atrophy, type 1 · score 0.77
- spinal muscular atrophy, type II · score 0.77
- spinal muscular atrophy · score 0.71
- Proximal spinal muscular atrophy type 2 · score 0.71
- spinal muscular atrophy, type IV · score 0.70
- Proximal spinal muscular atrophy type 4 · score 0.63
- proximal spinal muscular atrophy · score 0.54
- neurodegenerative disease · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q16637-F1 | alphafold | PREDICTED | 66.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q16637.
Amino-acid sequence (294 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SMN1?
DrugCentral lists 1 approved drug whose mechanism of action is SMN1: Nusinersen.
Which diseases are associated with SMN1?
The strongest Open Targets associations for SMN1 are Proximal spinal muscular atrophy type 3, spinal muscular atrophy, type III, spinal muscular atrophy, type 1, spinal muscular atrophy, type II and spinal muscular atrophy.
How long is the SMN1 protein?
The Homo sapiens SMN1 protein (UniProt Q16637) is 294 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q16637 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q16637 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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