About Carbonic anhydrase 9
Carbonic anhydrase 9 (CA9) is a protein
from Homo sapiens identified by UniProt accession
Q16790, 459 residues long.
MolForge cross-references it against 0 known binders and
448 disease associations.
Target properties
| Protein name | Carbonic anhydrase 9 |
|---|
| UniProt accession | Q16790 |
|---|
| Gene | CA9 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 459 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (448)
Diseases linked to this target (Open Targets).
- epilepsy · score 0.44
- neurodegenerative disease · score 0.36
- clear cell renal carcinoma · score 0.35
- kidney cancer · score 0.28
- renal carcinoma · score 0.19
- breast adenocarcinoma · score 0.18
- urate measurement · score 0.17
- renal cell carcinoma · score 0.14
- neoplasm · score 0.12
- non-small cell lung carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16790-F1 | alphafold | PREDICTED | 76.59 | — |
Amino-acid sequence (459 residues)
MAPLCPSPWL PLLIPAPAPG LTVQLLLSLL LLVPVHPQRL PRMQEDSPLG GGSSGEDDPL GEEDLPSEED SPREEDPPGE EDLPGEEDLP GEEDLPEVKP KSEEEGSLKL EDLPTVEAPG DPQEPQNNAH RDKEGDDQSH WRYGGDPPWP RVSPACAGRF QSPVDIRPQL AAFCPALRPL ELLGFQLPPL PELRLRNNGH SVQLTLPPGL EMALGPGREY RALQLHLHWG AAGRPGSEHT VEGHRFPAEI HVVHLSTAFA RVDEALGRPG GLAVLAAFLE EGPEENSAYE QLLSRLEEIA EEGSETQVPG LDISALLPSD FSRYFQYEGS LTTPPCAQGV IWTVFNQTVM LSAKQLHTLS DTLWGPGDSR LQLNFRATQP LNGRVIEASF PAGVDSSPRA AEPVQLNSCL AAGDILALVF GLLFAVTSVA FLVQMRRQHR RGTKGGVSYR PAEVAETGA
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