Anoctamin-1 (ANO1)
Homo sapiens — UniProt Q5XXA6
Data last refreshed: (UniProt release unknown)
Key facts
Anoctamin-1 (ANO1) is a protein from Homo sapiens identified by UniProt accession Q5XXA6, 986 residues long. MolForge cross-references it against 3 known binders and 454 disease associations.
- UniProt accession: Q5XXA6; gene symbol ANO1.
- Organism: Homo sapiens.
- Length: 986 amino acids.
- Approved drugs acting on it (DrugCentral): Crofelemer.
- Top disease associations (Open Targets): Diarrhea, body height and BMI-adjusted waist-hip ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Anoctamin-1 |
|---|---|
| UniProt accession | Q5XXA6 |
| Gene | ANO1 |
| Organism | Homo sapiens |
| Length | 986 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (454)
Diseases linked to this target (Open Targets).
- Diarrhea · score 0.53
- body height · score 0.45
- BMI-adjusted waist-hip ratio · score 0.42
- appendicular lean mass · score 0.40
- lean body mass · score 0.40
- COVID-19 · score 0.37
- AIDS · score 0.37
- Chronic diarrhea · score 0.37
- Recurrent infection of the gastrointestinal tract · score 0.37
- systolic blood pressure · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5XXA6-F1 | alphafold | PREDICTED | 76.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5XXA6.
Amino-acid sequence (986 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target ANO1?
DrugCentral lists 1 approved drug whose mechanism of action is ANO1: Crofelemer.
Which diseases are associated with ANO1?
The strongest Open Targets associations for ANO1 are Diarrhea, body height, BMI-adjusted waist-hip ratio, appendicular lean mass and lean body mass.
How long is the ANO1 protein?
The Homo sapiens ANO1 protein (UniProt Q5XXA6) is 986 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5XXA6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5XXA6 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.