Crofelemer
Antidiarrheal — ALIMENTARY TRACT AND METABOLISM
Also known as: fulyzaq
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Crofelemer is a drug in the Antidiarrheal class catalogued in DrugCentral. It was first approved by the FDA in 2012. DrugCentral lists 2 molecular targets, including ANO1 and CFTR. Recorded indications include Non-infective diarrhea.
- Drug class: Antidiarrheal.
- Molecular targets: ANO1 and CFTR (2 listed in DrugCentral).
- Indications: Non-infective diarrhea.
- ATC code: A07XA06 (Other antidiarrheals).
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Non-infective diarrhea
Mechanism & targets
| Established pharmacologic class | Antidiarrheal |
|---|
Molecular targets (2)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Anoctamin-1 | ANO1 | inhibitor | IC50 5.19 |
| Cystic fibrosis transmembrane conductance regulator | CFTR | inhibitor | IC50 5.16 |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 2012-12-31 | FDA | — | SALIX PHARMS |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
A07XA06 | ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › OTHER ANTIDIARRHEALS › Other antidiarrheals |
Chemical structure
| Molecular formula | — |
|---|---|
| Molecular weight | — |
| CAS number | 148465-45-6 |
| InChIKey | — |
| PubChem CID | — |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Crofelemer used for?
DrugCentral lists the following indications for Crofelemer: Non-infective diarrhea.
How does Crofelemer work?
Its molecular targets in DrugCentral include ANO1 (inhibitor) and CFTR (inhibitor).
When was Crofelemer first approved?
Crofelemer was first approved by the FDA in 2012.
What drug class does Crofelemer belong to?
Crofelemer is in the Antidiarrheal class.
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Sources
- DrugCentral drug card 4744 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL2108184 — compound record and bioactivity
- DrugBank DB04941 — drug record
- FDA UNII PY79D6C8RX — substance identity
- DailyMed: FDA labels for Crofelemer — current prescribing information (label search)
- UniProt Q5XXA6 (ANO1) — target protein
- UniProt P13569 (CFTR) — target protein
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