Racecadotril

ALIMENTARY TRACT AND METABOLISM

Key facts

Racecadotril is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1993. DrugCentral lists 10 molecular targets, including MME, MME and Mme. Recorded indications include Acute diarrhea.

• Molecular targets: MME, MME, Mme and MME (10 listed in DrugCentral).
• Indications: Acute diarrhea.
• ATC code: A07XA04 (Other antidiarrheals).
• Molecular formula: C21H23NO4S; molecular weight 385.48 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Acute diarrhea

Mechanism & targets

Molecular targets (10)

Target	Gene	Action	Activity
Neprilysin	MME	inhibitor	IC50 9.00
Neprilysin	MME	unknown	IC50 8.40
Neprilysin	Mme	unknown	IC50 8.32
Neprilysin	MME	unknown	IC50 8.21
Endothelin-converting enzyme 1	ECE1	unknown	IC50 8.10
Angiotensin-converting enzyme	ACE	unknown	IC50 6.50
Angiotensin-converting enzyme	ACE	unknown	IC50 6.38
Beta-lactamase NDM-1	blaNDM-1	unknown	IC50 5.75
Thermolysin	npr	unknown	IC50 5.02
Puromycin-sensitive aminopeptidase	NPEPPS	unknown	IC50 4.24

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1993-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
A07XA04	ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › OTHER ANTIDIARRHEALS › Other antidiarrheals

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Toxic epidermal necrolysis	231.5
Rash maculo-papular	192.5
Acute kidney injury	191.5
Hepatocellular injury	170.1
Hepatic cytolysis	167.3
Drug reaction with eosinophilia and systemic symptoms	148.2
Cholestasis	145.9
Alveolar lung disease	125.4
Eosinophilia	124.1
Pulmonary interstitial emphysema syndrome	118.4
Febrile bone marrow aplasia	98.4
Pancytopenia	90.6

Chemical structure

• Molecular formula: C₂₁H₂₃NO₄S
• Molecular weight: 385.48 g/mol
• CAS number: 81110-73-8
• InChIKey: ODUOJXZPIYUATO-UHFFFAOYSA-N
• PubChem CID: 107751

CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Racecadotril used for?

DrugCentral lists the following indications for Racecadotril: Acute diarrhea.

How does Racecadotril work?

Its molecular targets in DrugCentral include MME (inhibitor), MME, Mme and MME.

When was Racecadotril first approved?

Racecadotril was first approved by the YEAR INTRODUCED in 1993.

What is the chemical formula of Racecadotril?

Racecadotril has the molecular formula C21H23NO4S and a molecular weight of 385.48 g/mol.

Sources

• DrugCentral drug card 60 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL10247 — compound record and bioactivity
• PubChem CID 107751 — chemical identifiers
• DrugBank DB08626 — drug record
• FDA UNII 76K53XP4TO — substance identity
• UniProt P08473 (MME) — target protein
• UniProt P42892 (ECE1) — target protein
• UniProt P12821 (ACE) — target protein
• UniProt P55786 (NPEPPS) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.