About Potassium voltage-gated channel subfamily KQT member 5
Potassium voltage-gated channel subfamily KQT member 5 (KCNQ5) is a protein
from Homo sapiens identified by UniProt accession
Q9NR82, 932 residues long.
MolForge cross-references it against 4 known binders and
179 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
Approved drugs acting on this target (4)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (179)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.67
- autosomal dominant non-syndromic intellectual disability · score 0.63
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- Seizure · score 0.54
- epilepsy · score 0.54
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
- Myopia · score 0.46
- refractive error · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q9NR82.
Amino-acid sequence (932 residues)
MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS AAARGDGLLL LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ SCRRNVKYRR VQNYLYNVLE RPRGWAFIYH AFVFLLVFGC LILSVFSTIP EHTKLASSCL LILEFVMIVV FGLEFIIRIW SAGCCCRYRG WQGRLRFARK PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL RMVRMDRRGG TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF ALKVQEQHRQ KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL HTCSPTKKEQ GEASSSQKLS FKERVRMASP RGQSIKSRQA SVGDRRSPST DITAEGSPTK VQKSWSFNDR TRFRPSLRLK SSQPKPVIDA DTALGTDDVY DEKGCQCDVS VEDLTPPLKT VIRAIRIMKF HVAKRKFKET LRPYDVKDVI EQYSAGHLDM LCRIKSLQTR VDQILGKGQI TSDKKSREKI TAEHETTDDL SMLGRVVKVE KQVQSIESKL DCLLDIYQQV LRKGSASALA LASFQIPPFE CEQTSDYQSP VDSKDLSGSA QNSGCLSRST SANISRGLQF ILTPNEFSAQ TFYALSPTMH SQATQVPISQ SDGSAVAATN TIANQINTAP KPAAPTTLQI PPPLPAIKHL PRPETLHPNP AGLQESISDV TTCLVASKEN VQVAQSNLTK DRSMRKSFDM GGETLLSVCP MVPKDLGKSL SVQNLIRSTE ELNIQLSGSE SSGSRGSQDF YPKWRESKLF ITDEEVGPEE TETDTFDAAP QPAREAAFAS DSLRTGRSRS SQSICKAGES TDALSLPHVK LK
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