About Lethal(3)malignant brain tumor-like protein 1
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y468, 840 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Lethal(3)malignant brain tumor-like protein 1 |
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| UniProt accession | Q9Y468 |
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| Gene | L3MBTL1 |
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| Organism | Homo sapiens |
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| Length | 840 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (63)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.30
- monocyte count · score 0.27
- low grade glioma · score 0.25
- breast adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.25
- ovarian cancer · score 0.23
- body mass index · score 0.22
- mathematical ability · score 0.21
- self reported educational attainment · score 0.19
- lung adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y468-F1 | alphafold | PREDICTED | 63.87 | — |
Amino-acid sequence (840 residues)
MHLVAGDSPG SGPHLPATAF IIPASSATLG LPSSALDVSC FPREPIHVGA PEQVAGCEPV SATVLPQLSA GPASSSTSTV RLLEWTEAAA PPPGGGLRFR ISEYKPLNMA GVEQPPSPEL RQEGVTEYED GGAPAGDGEA GPQQAEDHPQ NPPEDPNQDP PEDDSTCQCQ ACGPHQAAGP DLGSSNDGCP QLFQERSVIV ENSSGSTSAS ELLKPMKKRK RREYQSPSEE ESEPEAMEKQ EEGKDPEGQP TASTPESEEW SSSQPATGEK KECWSWESYL EEQKAITAPV SLFQDSQAVT HNKNGFKLGM KLEGIDPQHP SMYFILTVAE VCGYRLRLHF DGYSECHDFW VNANSPDIHP AGWFEKTGHK LQPPKGYKEE EFSWSQYLRS TRAQAAPKHL FVSQSHSPPP LGFQVGMKLE AVDRMNPSLV CVASVTDVVD SRFLVHFDNW DDTYDYWCDP SSPYIHPVGW CQKQGKPLTP PQDYPDPDNF CWEKYLEETG ASAVPTWAFK VRPPHSFLVN MKLEAVDRRN PALIRVASVE DVEDHRIKIH FDGWSHGYDF WIDADHPDIH PAGWCSKTGH PLQPPLGPRE PSSASPGGCP PLSYRSLPHT RTSKYSFHHR KCPTPGCDGS GHVTGKFTAH HCLSGCPLAE RNQSRLKAEL SDSEASARKK NLSGFSPRKK PRHHGRIGRP PKYRKIPQED FQTLTPDVVH QSLFMSALSA HPDRSLSVCW EQHCKLLPGV AGISASTVAK WTIDEVFGFV QTLTGCEDQA RLFKDEARIV RVTHVSGKTL VWTVAQLGDL VCSDHLQEGK GILETGVHSL LCSLPTHLLA KLSFASDSQY
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