Benidipine

CARDIOVASCULAR SYSTEM

Key facts

Benidipine is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1991. DrugCentral lists 2 molecular targets, including CACNA1H and CACNA1D|CACNA1C.

• Molecular targets: CACNA1H and CACNA1D|CACNA1C (2 listed in DrugCentral).
• ATC code: C08CA15 (Dihydropyridine derivatives).
• Molecular formula: C28H31N3O6; molecular weight 505.57 g/mol.

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	blocker	IC50 6.84
Voltage-gated L-type calcium channel	CACNA1D|CACNA1C	blocker	IC50 5.31

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1991-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
C08CA15	CARDIOVASCULAR SYSTEM › CALCIUM CHANNEL BLOCKERS › SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS › Dihydropyridine derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Cerebral infarction	141.7
Renal impairment	100.7
Interstitial lung disease	87.0
Inappropriate antidiuretic hormone secretion	69.7
Cardiac failure	68.9
Hepatic function abnormal	67.9
Altered state of consciousness	63.6
Prinzmetal angina	60.5
Platelet count decreased	46.8
Blood pressure decreased	43.5
Drug interaction	36.4
Colon cancer	31.0

Chemical structure

• Molecular formula: C₂₈H₃₁N₃O₆
• Molecular weight: 505.57 g/mol
• CAS number: 105979-17-7
• InChIKey: QZVNQOLPLYWLHQ-GEPVFLLWSA-N
• PubChem CID: 656668

COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)O[C@@H]1CCCN(CC2=CC=CC=C2)C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Benidipine work?

Its molecular targets in DrugCentral include CACNA1H (blocker) and CACNA1D|CACNA1C (blocker).

When was Benidipine first approved?

Benidipine was first approved by the YEAR INTRODUCED in 1991.

What is the chemical formula of Benidipine?

Benidipine has the molecular formula C28H31N3O6 and a molecular weight of 505.57 g/mol.

Sources

• DrugCentral drug card 3880 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2074972 — compound record and bioactivity
• PubChem CID 656668 — chemical identifiers
• DrugBank DB09231 — drug record
• FDA UNII 4G9T91JS7E — substance identity
• UniProt O95180 (CACNA1H) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.