Manidipine

CARDIOVASCULAR SYSTEM

Key facts

Manidipine is a drug catalogued in DrugCentral. DrugCentral lists 2 molecular targets, including Cruzipain and CACNA1D|CACNA1C.

• Molecular targets: Cruzipain and CACNA1D|CACNA1C (2 listed in DrugCentral).
• ATC code: C08CA11 (Dihydropyridine derivatives).
• Molecular formula: C35H38N4O6; molecular weight 610.71 g/mol.

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Cruzipain	—	unknown	IC50 5.22
Voltage-gated L-type calcium channel	CACNA1D|CACNA1C	blocker	—

ATC classification

ATC code	Therapeutic hierarchy
C08CA11	CARDIOVASCULAR SYSTEM › CALCIUM CHANNEL BLOCKERS › SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS › Dihydropyridine derivatives
C09BB12	CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, COMBINATIONS › ACE inhibitors and calcium channel blockers

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug interaction	143.1
Hyponatraemia	114.4
Trichoglossia	95.9
Acute kidney injury	84.0
Parkinsonism	54.3
Immune-mediated thyroiditis	53.2
Hypomagnesaemia	52.2
Dermatitis bullous	39.5
Post transplant lymphoproliferative disorder	33.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Manidipine is on its molecule page.

• Molecular formula: C₃₅H₃₈N₄O₆
• Molecular weight: 610.71 g/mol
• CAS number: 89226-50-6
• InChIKey: ANEBWFXPVPTEET-UHFFFAOYSA-N
• PubChem CID: 4008

COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Manidipine work?

Its molecular targets in DrugCentral include Cruzipain and CACNA1D|CACNA1C (blocker).

What is the chemical formula of Manidipine?

Manidipine has the molecular formula C35H38N4O6 and a molecular weight of 610.71 g/mol.

Sources

• DrugCentral drug card 1631 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1085699 — compound record and bioactivity
• PubChem CID 4008 — chemical identifiers
• DrugBank DB09238 — drug record
• FDA UNII 6O4754US88 — substance identity
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.