Benazepril

Angiotensin Converting Enzyme Inhibitor — CARDIOVASCULAR SYSTEM

Key facts

Benazepril is an ofp drug in the Angiotensin Converting Enzyme Inhibitor class catalogued in DrugCentral. It was first approved by the FDA in 1991. Its mechanism of action is classified as Angiotensin-converting Enzyme Inhibitors. DrugCentral lists 3 molecular targets, including Ace, ACE and ACE. Recorded indications include Hypertensive disorder.

• Approval status: ofp (first approved 1991 by the FDA).
• Drug class: Angiotensin Converting Enzyme Inhibitor.
• Mechanism of action: Angiotensin-converting Enzyme Inhibitors.
• Molecular targets: Ace, ACE and ACE (3 listed in DrugCentral).
• Indications: Hypertensive disorder.
• ATC code: C09AA07 (ACE inhibitors, plain).
• Molecular formula: C24H28N2O5; molecular weight 424.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Hypertensive disorder

Off-label uses (7)

• Acute scleroderma renal crisis
• Atrial fibrillation
• Chronic heart failure
• Diabetic renal disease
• Diastolic heart failure
• Hypertension due to Scleroderma
• Nondiabetic Proteinuric Nephropathy

Contraindications (39)

• Acute pancreatitis
• Angioedema
• Anuria
• Azotemia
• Bone marrow depression
• Chronic idiopathic constipation
• Dehydration
• Diabetes mellitus
• Disease of liver
• Disorder of connective tissue
• Gout
• Head and Neck Angioedema
• Hemodialysis with High-Flux Membrane
• Hepatic coma
• Hepatic failure
• Hereditary angioneurotic edema
• Hypercalcemia
• Hypercholesterolemia
• Hyperkalemia
• Hyperparathyroidism
• Hyperuricemia
• Hypochloremic alkalosis
• Hypokalemia
• Hypomagnesemia
• Hyponatremia
• Hypovolemia
• Intestinal Angioedema
• Jaundice
• Kidney disease
• Liver function tests abnormal
• + 9 more

Mechanism & targets

• Mechanism of action (MoA): Angiotensin-converting Enzyme Inhibitors
• Established pharmacologic class: Angiotensin Converting Enzyme Inhibitor

Molecular targets (3)

Target	Gene	Action	Activity
Angiotensin-converting enzyme	Ace	unknown	IC50 8.77
Angiotensin-converting enzyme	ACE	unknown	IC50 8.70
Angiotensin-converting enzyme	ACE	inhibitor	IC50 6.51

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1991-06-25	FDA	—	US PHARMS HOLDINGS I

ATC classification

ATC code	Therapeutic hierarchy
C09AA07	CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, PLAIN › ACE inhibitors, plain
C09BA07	CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, COMBINATIONS › ACE inhibitors and diuretics
C09BB13	CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, COMBINATIONS › ACE inhibitors and calcium channel blockers

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Angioedema	405.1
Myocardial infarction	322.8
Coronary artery disease	260.9
Cardiac failure congestive	244.4
Cerebrovascular accident	231.1
Off label use	180.6
Maternal exposure during pregnancy	83.3
Contraindicated product administered	77.0
Completed suicide	76.0
Hand deformity	73.5
Systemic lupus erythematosus	73.1
Infusion related reaction	72.7

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Benazepril is on its molecule page.

• Molecular formula: C₂₄H₂₈N₂O₅
• Molecular weight: 424.50 g/mol
• CAS number: 86541-75-5
• InChIKey: XPCFTKFZXHTYIP-PMACEKPBSA-N
• PubChem CID: 5362124

CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]1CCC2=CC=CC=C2N(CC(O)=O)C1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Benazepril used for?

DrugCentral lists the following indications for Benazepril: Hypertensive disorder.

How does Benazepril work?

Benazepril is classified as Angiotensin-converting Enzyme Inhibitors; its molecular targets in DrugCentral include Ace, ACE and ACE (inhibitor).

When was Benazepril first approved?

Benazepril was first approved by the FDA in 1991.

What drug class does Benazepril belong to?

Benazepril is in the Angiotensin Converting Enzyme Inhibitor class.

What is the chemical formula of Benazepril?

Benazepril has the molecular formula C24H28N2O5 and a molecular weight of 424.50 g/mol.

Sources

• DrugCentral drug card 299 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1192519 — compound record and bioactivity
• PubChem CID 5362124 — chemical identifiers
• DrugBank DB00542 — drug record
• FDA UNII JRM708L703 — substance identity
• DailyMed: FDA labels for Benazepril — current prescribing information (label search)
• UniProt P12821 (ACE) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.