Bromhexine

RESPIRATORY SYSTEM

Key facts

Bromhexine is a drug catalogued in DrugCentral. DrugCentral lists 4 molecular targets, including SIGMAR1, Pgrmc1 and CYP2D6.

• Molecular targets: SIGMAR1, Pgrmc1, CYP2D6 and SLC6A4 (4 listed in DrugCentral).
• ATC code: R05CB02 (Mucolytics).
• Molecular formula: C14H20Br2N2; molecular weight 376.14 g/mol.

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	Ki 7.60
Membrane-associated progesterone receptor component 1	Pgrmc1	unknown	Ki 7.44
Cytochrome P450 2D6	CYP2D6	unknown	IC50 6.71
Sodium-dependent serotonin transporter	SLC6A4	unknown	Ki 5.95

ATC classification

ATC code	Therapeutic hierarchy
R05CB02	RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS › Mucolytics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Pneumonia aspiration	170.2
Chronic sinusitis	140.2
Vaginal flatulence	92.7
Central nervous system mass	89.9
Wall motion score index abnormal	89.8
Airway remodelling	87.3
Female genital tract fistula	87.1
Atopy	83.2
Proctitis	81.7
Radiculopathy	81.5
Vaginal discharge	80.8
Eosinophilic myocarditis	74.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Bromhexine is on its molecule page.

• Molecular formula: C₁₄H₂₀Br₂N₂
• Molecular weight: 376.14 g/mol
• CAS number: —
• InChIKey: OJGDCBLYJGHCIH-UHFFFAOYSA-N
• PubChem CID: 2442

CN(CC1=C(N)C(Br)=CC(Br)=C1)C1CCCCC1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Bromhexine work?

Its molecular targets in DrugCentral include SIGMAR1, Pgrmc1, CYP2D6 and SLC6A4.

What is the chemical formula of Bromhexine?

Bromhexine has the molecular formula C14H20Br2N2 and a molecular weight of 376.14 g/mol.

Sources

• DrugCentral drug card 402 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1319139 — compound record and bioactivity
• PubChem CID 2442 — chemical identifiers
• DrugBank DB09019 — drug record
• FDA UNII Q1J152VB1P — substance identity
• UniProt Q99720 (SIGMAR1) — target protein
• UniProt P10635 (CYP2D6) — target protein
• UniProt P31645 (SLC6A4) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.