Cefdinir

Cephalosporin Antibacterial — ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cefdinir is an ofp drug in the Cephalosporin Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 1997. DrugCentral lists 5 molecular targets, including mex-5, pos-1 and mecA. Recorded indications include Acute bacterial sinusitis, Acute Moraxella catarrhalis bronchitis, Haemophilus Influenzae Bronchitis and Haemophilus influenzae pneumonia.

• Approval status: ofp (first approved 1997 by the FDA).
• Drug class: Cephalosporin Antibacterial.
• Molecular targets: mex-5, pos-1, mecA and pbp3 (5 listed in DrugCentral).
• Indications: Acute bacterial sinusitis, Acute Moraxella catarrhalis bronchitis, Haemophilus Influenzae Bronchitis, Haemophilus influenzae pneumonia and Haemophilus Parainfluenzae Bronchitis and others.
• ATC code: J01DD15 (Third-generation cephalosporins).
• Molecular formula: C14H13N5O5S2; molecular weight 395.41 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (13)

• Acute bacterial sinusitis
• Acute Moraxella catarrhalis bronchitis
• Haemophilus Influenzae Bronchitis
• Haemophilus influenzae pneumonia
• Haemophilus Parainfluenzae Bronchitis
• Haemophilus Parainfluenzae Pneumonia
• Infection due to Staphylococcus aureus
• Infective otitis media
• Moraxella Catarrhalis Pneumonia
• Pneumonia due to Streptococcus
• Streptococcal tonsillitis
• Streptococcus Pneumoniae Bronchitis
• Streptococcus pyogenes infection

Off-label uses (1)

• Pyrexia of unknown origin

Contraindications (2)

• Acute nephropathy
• Pseudomembranous enterocolitis

Mechanism & targets

• Established pharmacologic class: Cephalosporin Antibacterial

Molecular targets (5)

Target	Gene	Action	Activity
Zinc finger protein mex-5	mex-5	unknown	EC50 4.48
Cytoplasmic zinc-finger protein	pos-1	unknown	EC50 4.30
Pencillin binding protein 2a; Penicillin binding protein 2'; Penicillin binding protein, PBP2; Penicillin-binding protein 2; Penicillin-binding protein 2'; Peptidase	mecA	unknown	—
Penicillin-binding protein 3	pbp3	unknown	—
Bacterial penicillin-binding protein	mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1997-12-04	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
J01DD15	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Third-generation cephalosporins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Product storage error	136.7
Sinusitis	110.0
No adverse event	104.2
Pneumonia	96.4
Faeces discoloured	94.1
Drug hypersensitivity	81.2
Urinary tract infection	62.1
Product dose omission issue	51.6
Bronchitis	47.6
Vanishing bile duct syndrome	45.6
Ear infection	32.6
Stevens-Johnson syndrome	32.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Cefdinir is on its molecule page.

• Molecular formula: C₁₄H₁₃N₅O₅S₂
• Molecular weight: 395.41 g/mol
• CAS number: 91832-40-5
• InChIKey: RTXOFQZKPXMALH-GHXIOONMSA-N
• PubChem CID: 6915944

NC1=NC(=CS1)C(=N\O)\C(=O)N[C@H]1[C@H]2SCC(C=C)=C(N2C1=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cefdinir used for?

DrugCentral lists the following indications for Cefdinir: Acute bacterial sinusitis, Acute Moraxella catarrhalis bronchitis, Haemophilus Influenzae Bronchitis, Haemophilus influenzae pneumonia, Haemophilus Parainfluenzae Bronchitis, Haemophilus Parainfluenzae Pneumonia, Infection due to Staphylococcus aureus and Infective otitis media and others.

How does Cefdinir work?

Its molecular targets in DrugCentral include mex-5, pos-1, mecA and pbp3.

When was Cefdinir first approved?

Cefdinir was first approved by the FDA in 1997.

What drug class does Cefdinir belong to?

Cefdinir is in the Cephalosporin Antibacterial class.

What is the chemical formula of Cefdinir?

Cefdinir has the molecular formula C14H13N5O5S2 and a molecular weight of 395.41 g/mol.

Sources

• DrugCentral drug card 533 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL927 — compound record and bioactivity
• PubChem CID 6915944 — chemical identifiers
• DrugBank DB00535 — drug record
• FDA UNII CI0FAO63WC — substance identity
• DailyMed: FDA labels for Cefdinir — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.