Cefoperazone

Cephalosporin Antibacterial — ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cefoperazone is an ofm drug in the Cephalosporin Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 1982. DrugCentral lists 2 molecular targets, including pbpA and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB.

• Approval status: ofm (first approved 1982 by the FDA).
• Drug class: Cephalosporin Antibacterial.
• Molecular targets: pbpA and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (2 listed in DrugCentral).
• ATC code: J01DD12 (Third-generation cephalosporins).
• Molecular formula: C25H27N9O8S2; molecular weight 645.67 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (7)

• Alcohol intoxication
• Blood coagulation disorder
• Disease of liver
• Disorder of digestive system
• Factor II deficiency
• Pseudomembranous enterocolitis
• Vitamin K deficiency

Mechanism & targets

• Established pharmacologic class: Cephalosporin Antibacterial

Molecular targets (2)

Target	Gene	Action	Activity
Penicillin-binding protein 1A	pbpA	unknown	—
Bacterial penicillin-binding protein	mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1982-11-18	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
J01DD12	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Third-generation cephalosporins
J01DD62	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Third-generation cephalosporins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Multiple organ dysfunction syndrome	44.7

Chemical structure

• Molecular formula: C₂₅H₂₇N₉O₈S₂
• Molecular weight: 645.67 g/mol
• CAS number: 62893-19-0
• InChIKey: GCFBRXLSHGKWDP-XCGNWRKASA-N
• PubChem CID: 44187

CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSC4=NN=NN4C)=C(N3C2=O)C(O)=O)C2=CC=C(O)C=C2)C(=O)C1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Cefoperazone work?

Its molecular targets in DrugCentral include pbpA and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (inhibitor).

When was Cefoperazone first approved?

Cefoperazone was first approved by the FDA in 1982.

What drug class does Cefoperazone belong to?

Cefoperazone is in the Cephalosporin Antibacterial class.

What is the chemical formula of Cefoperazone?

Cefoperazone has the molecular formula C25H27N9O8S2 and a molecular weight of 645.67 g/mol.

Sources

• DrugCentral drug card 543 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200482 — compound record and bioactivity
• PubChem CID 44187 — chemical identifiers
• DrugBank DB01329 — drug record
• FDA UNII 7U75I1278D — substance identity
• DailyMed: FDA labels for Cefoperazone — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.