Cloxacillin

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cloxacillin is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1974. DrugCentral lists 7 molecular targets, including sugE, bla LAT-2 and blaACC-4. Recorded indications include Acute bacterial sinusitis, Continuation Therapy for Acute Osteomyelitis, Continuation Therapy for Chronic Osteomyelitis and Infection due to Staphylococcus aureus.

• Approval status: ofm (first approved 1974 by the FDA).
• Molecular targets: sugE, bla LAT-2, blaACC-4 and bla (7 listed in DrugCentral).
• Indications: Acute bacterial sinusitis, Continuation Therapy for Acute Osteomyelitis, Continuation Therapy for Chronic Osteomyelitis, Infection due to Staphylococcus aureus and Infection of skin AND/OR subcutaneous tissue and others.
• ATC code: J01CF02 (Beta-lactamase resistant penicillins).
• Molecular formula: C19H18ClN3O5S; molecular weight 435.88 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (14)

• Acute bacterial sinusitis
• Continuation Therapy for Acute Osteomyelitis
• Continuation Therapy for Chronic Osteomyelitis
• Infection due to Staphylococcus aureus
• Infection of skin AND/OR subcutaneous tissue
• Lower respiratory tract infection
• Pharyngitis
• Sinusitis
• Staphylococcal meningitis
• Staphylococcal pneumonia
• Staphylococcal septicemia
• Staphylococcus Aureus Bronchitis
• Staphylococcus Aureus Urinary Tract Infection
• Staphylococcus Epidermidis Urinary Tract Infection

Off-label uses (4)

• Bacterial endocarditis
• Cholangitis
• Diabetic Foot Infection Due to Gram-Positive Bacteria
• Pyrexia of unknown origin

Contraindications (3)

• Infectious mononucleosis
• Kidney disease
• Pseudomembranous enterocolitis

Mechanism & targets

Molecular targets (7)

Target	Gene	Action	Activity
Efflux transporter; SugE	sugE	unknown	IC50 8.40
Beta-lactamase	bla LAT-2	unknown	IC50 8.40
Beta-lactamase	blaACC-4	unknown	IC50 7.59
Beta-lactamase TEM	bla	unknown	Ki 4.89
Beta-lactamase TEM	bla; blaT-3; blaT-4;	unknown	Ki 4.89
Penicillin-binding protein 1A	pbpA	unknown	—
Penicillin-binding protein	pbp4|mecA|pbpA|PBP2|pbpF	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1974-09-17	FDA	—	GLAXOSMITHKLINE

ATC classification

ATC code	Therapeutic hierarchy
J01CF02	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › BETA-LACTAM ANTIBACTERIALS, PENICILLINS › Beta-lactamase resistant penicillins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug reaction with eosinophilia and systemic symptoms	409.9
Acute kidney injury	352.2
Agranulocytosis	125.4
Rash maculo-papular	118.9
Eosinophilia	89.5
Cholestasis	88.6
Tubulointerstitial nephritis	81.3
Hepatocellular injury	71.0
Jaundice	68.7
Toxic epidermal necrolysis	57.7
Thrombocytopenia	57.0
Nephritis allergic	52.6

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Cloxacillin is on its molecule page.

• Molecular formula: C₁₉H₁₈ClN₃O₅S
• Molecular weight: 435.88 g/mol
• CAS number: 61-72-3
• InChIKey: LQOLIRLGBULYKD-JKIFEVAISA-N
• PubChem CID: 6098

CC1=C(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(O)=O)C(=NO1)C1=C(Cl)C=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cloxacillin used for?

DrugCentral lists the following indications for Cloxacillin: Acute bacterial sinusitis, Continuation Therapy for Acute Osteomyelitis, Continuation Therapy for Chronic Osteomyelitis, Infection due to Staphylococcus aureus, Infection of skin AND/OR subcutaneous tissue, Lower respiratory tract infection, Pharyngitis and Sinusitis and others.

How does Cloxacillin work?

Its molecular targets in DrugCentral include sugE, bla LAT-2, blaACC-4 and bla.

When was Cloxacillin first approved?

Cloxacillin was first approved by the FDA in 1974.

What is the chemical formula of Cloxacillin?

Cloxacillin has the molecular formula C19H18ClN3O5S and a molecular weight of 435.88 g/mol.

Sources

• DrugCentral drug card 720 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200388 — compound record and bioactivity
• PubChem CID 6098 — chemical identifiers
• DrugBank DB01147 — drug record
• FDA UNII O6X5QGC2VB — substance identity
• DailyMed: FDA labels for Cloxacillin — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.