Meticillin

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Meticillin is an ofm drug catalogued in DrugCentral. DrugCentral lists 3 molecular targets, including nadE, pbp and pbp4|mecA|pbpA|PBP2|pbpF. Recorded indications include Bacterial septicemia, Infection of skin AND/OR subcutaneous tissue, Sinusitis and Staphylococcal pneumonia.

• Approval status: ofm.
• Molecular targets: nadE, pbp and pbp4|mecA|pbpA|PBP2|pbpF (3 listed in DrugCentral).
• Indications: Bacterial septicemia, Infection of skin AND/OR subcutaneous tissue, Sinusitis and Staphylococcal pneumonia.
• ATC code: J01CF03 (Beta-lactamase resistant penicillins).
• Molecular formula: C17H20N2O6S; molecular weight 380.42 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Bacterial septicemia
• Infection of skin AND/OR subcutaneous tissue
• Sinusitis
• Staphylococcal pneumonia

Off-label uses (3)

• Bacterial endocarditis
• Cholangitis
• Staphylococcal meningitis

Contraindications (3)

• Infectious mononucleosis
• Kidney disease
• Pseudomembranous enterocolitis

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
NH(3)-dependent NAD(+) synthetase	nadE	unknown	IC50 5.50
Beta-lactam-inducible penicillin-binding protein	pbp	unknown	—
Penicillin-binding protein	pbp4|mecA|pbpA|PBP2|pbpF	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	APOTHECON

ATC classification

ATC code	Therapeutic hierarchy
J01CF03	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › BETA-LACTAM ANTIBACTERIALS, PENICILLINS › Beta-lactamase resistant penicillins

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Meticillin is on its molecule page.

• Molecular formula: C₁₇H₂₀N₂O₆S
• Molecular weight: 380.42 g/mol
• CAS number: —
• InChIKey: RJQXTJLFIWVMTO-TYNCELHUSA-N
• PubChem CID: 6087

COC1=CC=CC(OC)=C1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Meticillin used for?

DrugCentral lists the following indications for Meticillin: Bacterial septicemia, Infection of skin AND/OR subcutaneous tissue, Sinusitis and Staphylococcal pneumonia.

How does Meticillin work?

Its molecular targets in DrugCentral include nadE, pbp and pbp4|mecA|pbpA|PBP2|pbpF (inhibitor).

What is the chemical formula of Meticillin?

Meticillin has the molecular formula C17H20N2O6S and a molecular weight of 380.42 g/mol.

Sources

• DrugCentral drug card 1744 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3181832 — compound record and bioactivity
• PubChem CID 6087 — chemical identifiers
• DrugBank DB01603 — drug record
• FDA UNII Q91FH1328A — substance identity
• DailyMed: FDA labels for Meticillin — current prescribing information (label search)

How this page is built: methodology · editorial policy & corrections.