Floxacillin

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Floxacillin is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1962. DrugCentral lists 3 molecular targets, including AR, MMP9 and pbpA.

• Molecular targets: AR, MMP9 and pbpA (3 listed in DrugCentral).
• ATC code: J01CF05 (Beta-lactamase resistant penicillins).
• Molecular formula: C19H17ClFN3O5S; molecular weight 453.87 g/mol.

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Androgen receptor	AR	unknown	IC50 6.25
Matrix metalloproteinase-9	MMP9	unknown	IC50 4.19
Penicillin-binding protein 1A	pbpA	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1962-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
J01CF05	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › BETA-LACTAM ANTIBACTERIALS, PENICILLINS › Beta-lactamase resistant penicillins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Metabolic acidosis	820.0
Drug interaction	537.3
Pyroglutamic acidosis	517.7
Pyroglutamate increased	247.9
Cellulitis	176.8
Acute kidney injury	152.3
Drug level decreased	140.9
Immunosuppressant drug level decreased	103.7
Acidosis	98.3
Lip swelling	94.8
Drug reaction with eosinophilia and systemic symptoms	94.0
Stevens-Johnson syndrome	84.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Floxacillin is on its molecule page.

• Molecular formula: C₁₉H₁₇ClFN₃O₅S
• Molecular weight: 453.87 g/mol
• CAS number: 5250-39-5
• InChIKey: UIOFUWFRIANQPC-JKIFEVAISA-N
• PubChem CID: 21319

CC1=C(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(O)=O)C(=NO1)C1=C(Cl)C=CC=C1F

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Floxacillin work?

Its molecular targets in DrugCentral include AR, MMP9 and pbpA.

When was Floxacillin first approved?

Floxacillin was first approved by the YEAR INTRODUCED in 1962.

What is the chemical formula of Floxacillin?

Floxacillin has the molecular formula C19H17ClFN3O5S and a molecular weight of 453.87 g/mol.

Sources

• DrugCentral drug card 1183 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL222645 — compound record and bioactivity
• PubChem CID 21319 — chemical identifiers
• DrugBank DB00301 — drug record
• FDA UNII 43B2M34G2V — substance identity
• UniProt P10275 (AR) — target protein
• UniProt P14780 (MMP9) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.