Decamethonium

Drug profile

Key facts

Decamethonium is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1975. DrugCentral lists 6 molecular targets, including CHRM2, HRH3 and Ache.

• Approval status: ofm (first approved 1975 by the FDA).
• Molecular targets: CHRM2, HRH3, Ache and Chrna4|Chrnb2 (6 listed in DrugCentral).
• Molecular formula: C16H38N2; molecular weight 258.49 g/mol.

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 7.60
Histamine H3 receptor	HRH3	unknown	IC50 6.09
Acetylcholinesterase	Ache	unknown	Ki 5.46
Neuronal acetylcholine receptor; alpha4/beta2	Chrna4|Chrnb2	unknown	Ki 5.24
Acetylcholinesterase	ACHE	unknown	IC50 5.23
Muscle-type nicotinic acetylcholine receptor	CHRNA1|CHRNG|CHRNB1|CHRNE|CHRND	partial agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1975-05-21	FDA	—	—

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Decamethonium is on its molecule page.

• Molecular formula: C₁₆H₃₈N₂
• Molecular weight: 258.49 g/mol
• CAS number: 156-74-1
• InChIKey: MTCUAOILFDZKCO-UHFFFAOYSA-N
• PubChem CID: 2968

C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Decamethonium work?

Its molecular targets in DrugCentral include CHRM2, HRH3, Ache and Chrna4|Chrnb2.

When was Decamethonium first approved?

Decamethonium was first approved by the FDA in 1975.

What is the chemical formula of Decamethonium?

Decamethonium has the molecular formula C16H38N2 and a molecular weight of 258.49 g/mol.

Sources

• DrugCentral drug card 789 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1134 — compound record and bioactivity
• PubChem CID 2968 — chemical identifiers
• DrugBank DB01245 — drug record
• FDA UNII C1CG1S3T2W — substance identity
• DailyMed: FDA labels for Decamethonium — current prescribing information (label search)
• UniProt P08172 (CHRM2) — target protein
• UniProt Q9Y5N1 (HRH3) — target protein
• UniProt P22303 (ACHE) — target protein

How this page is built: methodology · editorial policy & corrections.