Fendiline
CARDIOVASCULAR SYSTEM
Also known as: (+/-)-Fendiline, fendilin, fendiline HCl, fendiline hydrochloride, phendilin
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Fendiline is a drug catalogued in DrugCentral. DrugCentral lists 6 molecular targets, including CALM, CASR and HTR2B. Recorded indications include Ischemic heart disease.
- Molecular targets: CALM, CASR, HTR2B and SMPD1 (6 listed in DrugCentral).
- Indications: Ischemic heart disease.
- ATC code: C08EA01 (Phenylalkylamine derivatives).
- Molecular formula: C23H25N; molecular weight 315.46 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Ischemic heart disease
Mechanism & targets
Molecular targets (6)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Calmodulin | CALM | unknown | Kd 6.30 |
| Extracellular calcium-sensing receptor | CASR | unknown | EC50 6.00 |
| 5-hydroxytryptamine receptor 2B | HTR2B | unknown | Ki 5.49 |
| Sphingomyelin phosphodiesterase | SMPD1 | unknown | IC50 5.25 |
| Extracellular calcium-sensing receptor | CASR | positive allosteric modulator | EC50 4.92 |
| Transcriptional activator protein luxR | luxR | unknown | IC50 4.04 |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
C08EA01 | CARDIOVASCULAR SYSTEM › CALCIUM CHANNEL BLOCKERS › NON-SELECTIVE CALCIUM CHANNEL BLOCKERS › Phenylalkylamine derivatives |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Fendiline is on its molecule page.
| Molecular formula | C23H25N |
|---|---|
| Molecular weight | 315.46 g/mol |
| CAS number | 13042-18-7 |
| InChIKey | NMKSAYKQLCHXDK-UHFFFAOYSA-N |
| PubChem CID | 3336 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Fendiline used for?
DrugCentral lists the following indications for Fendiline: Ischemic heart disease.
How does Fendiline work?
Its molecular targets in DrugCentral include CALM, CASR, HTR2B and SMPD1.
What is the chemical formula of Fendiline?
Fendiline has the molecular formula C23H25N and a molecular weight of 315.46 g/mol.
Browse: all drugs starting with F · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 1148 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1405922 — compound record and bioactivity
- PubChem CID 3336 — chemical identifiers
- DrugBank DB08980 — drug record
- FDA UNII S253D559A8 — substance identity
- UniProt P41180 (CASR) — target protein
- UniProt P41595 (HTR2B) — target protein
- UniProt P17405 (SMPD1) — target protein
How this page is built: methodology · editorial policy & corrections.
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