Isocarboxazid

Monoamine Oxidase Inhibitor — NERVOUS SYSTEM

Key facts

Isocarboxazid is an ofp drug in the Monoamine Oxidase Inhibitor class catalogued in DrugCentral. It was first approved by the FDA in 1959. Its mechanism of action is classified as Monoamine Oxidase Inhibitors. DrugCentral lists 2 molecular targets, including MAOB and MAOA. Recorded indications include Major depressive disorder.

• Approval status: ofp (first approved 1959 by the FDA).
• Drug class: Monoamine Oxidase Inhibitor.
• Mechanism of action: Monoamine Oxidase Inhibitors.
• Molecular targets: MAOB and MAOA (2 listed in DrugCentral).
• Indications: Major depressive disorder.
• ATC code: N06AF01 (Monoamine oxidase inhibitors, non-selective).
• Molecular formula: C12H13N3O2; molecular weight 231.25 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Major depressive disorder

Contraindications (28)

• Alcoholism
• Angina pectoris
• Anxiety
• Bipolar disorder
• Cerebrovascular disease
• Chronic heart failure
• Conduction disorder of the heart
• Diabetes mellitus
• Disease of liver
• Disorder of cardiovascular system
• Disorder of coronary artery
• Feeling agitated
• Frequent Headache Disorder
• Hypertensive disorder
• Hypertensive Emergencies
• Hyperthyroidism
• Hypoglycemic disorder
• Kidney disease
• Liver function tests abnormal
• Low blood pressure
• Myelogram
• Orthostatic hypotension
• Pheochromocytoma
• Schizophrenia
• Seizure disorder
• Severe Headache Disorder
• Suicidal thoughts
• Syncope

Mechanism & targets

• Mechanism of action (MoA): Monoamine Oxidase Inhibitors
• Established pharmacologic class: Monoamine Oxidase Inhibitor

Molecular targets (2)

Target	Gene	Action	Activity
Amine oxidase [flavin-containing] B	MAOB	inhibitor	—
Amine oxidase [flavin-containing] A	MAOA	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1959-07-01	FDA	—	VALIDUS PHARMS INC

ATC classification

ATC code	Therapeutic hierarchy
N06AF01	NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTIDEPRESSANTS › Monoamine oxidase inhibitors, non-selective

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Isocarboxazid is on its molecule page.

• Molecular formula: C₁₂H₁₃N₃O₂
• Molecular weight: 231.25 g/mol
• CAS number: 59-63-2
• InChIKey: XKFPYPQQHFEXRZ-UHFFFAOYSA-N
• PubChem CID: 3759

CC1=CC(=NO1)C(=O)NNCC1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Isocarboxazid used for?

DrugCentral lists the following indications for Isocarboxazid: Major depressive disorder.

How does Isocarboxazid work?

Isocarboxazid is classified as Monoamine Oxidase Inhibitors; its molecular targets in DrugCentral include MAOB (inhibitor) and MAOA (inhibitor).

When was Isocarboxazid first approved?

Isocarboxazid was first approved by the FDA in 1959.

What drug class does Isocarboxazid belong to?

Isocarboxazid is in the Monoamine Oxidase Inhibitor class.

What is the chemical formula of Isocarboxazid?

Isocarboxazid has the molecular formula C12H13N3O2 and a molecular weight of 231.25 g/mol.

Sources

• DrugCentral drug card 1490 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201168 — compound record and bioactivity
• PubChem CID 3759 — chemical identifiers
• DrugBank DB01247 — drug record
• FDA UNII 34237V843T — substance identity
• DailyMed: FDA labels for Isocarboxazid — current prescribing information (label search)
• UniProt P27338 (MAOB) — target protein
• UniProt P21397 (MAOA) — target protein

How this page is built: methodology · editorial policy & corrections.