Pargyline

CARDIOVASCULAR SYSTEM

Key facts

Pargyline is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1961. DrugCentral lists 5 molecular targets, including MAOB, MAOA and Maob. Recorded indications include Hypertensive disorder.

• Approval status: ofm (first approved 1961 by the FDA).
• Molecular targets: MAOB, MAOA, Maob and Aldh2 (5 listed in DrugCentral).
• Indications: Hypertensive disorder.
• ATC code: C02KC01 (MAO inhibitors).
• Molecular formula: C11H13N; molecular weight 159.23 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Hypertensive disorder

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Amine oxidase [flavin-containing] B	MAOB	inhibitor	Ki 5.74
Amine oxidase [flavin-containing] A	MAOA	inhibitor	IC50 5.47
Amine oxidase [flavin-containing] B	Maob	unknown	Ki 5.47
Aldehyde dehydrogenase, mitochondrial	Aldh2	unknown	IC50 5.25
Amine oxidase [flavin-containing] A	Maoa	unknown	Ki 5.07

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1961-01-01	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
C02KC01	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › OTHER ANTIHYPERTENSIVES › MAO inhibitors
C02LL01	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION › MAO inhibitors and diuretics

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Pargyline is on its molecule page.

• Molecular formula: C₁₁H₁₃N
• Molecular weight: 159.23 g/mol
• CAS number: 555-57-7
• InChIKey: DPWPWRLQFGFJFI-UHFFFAOYSA-N
• PubChem CID: 4688

CN(CC#C)CC1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Pargyline used for?

DrugCentral lists the following indications for Pargyline: Hypertensive disorder.

How does Pargyline work?

Its molecular targets in DrugCentral include MAOB (inhibitor), MAOA (inhibitor), Maob and Aldh2.

When was Pargyline first approved?

Pargyline was first approved by the FDA in 1961.

What is the chemical formula of Pargyline?

Pargyline has the molecular formula C11H13N and a molecular weight of 159.23 g/mol.

Sources

• DrugCentral drug card 2065 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200425 — compound record and bioactivity
• PubChem CID 4688 — chemical identifiers
• DrugBank DB01626 — drug record
• FDA UNII 9MV14S8G3E — substance identity
• DailyMed: FDA labels for Pargyline — current prescribing information (label search)
• UniProt P27338 (MAOB) — target protein
• UniProt P21397 (MAOA) — target protein

How this page is built: methodology · editorial policy & corrections.