Rebamipide

ALIMENTARY TRACT AND METABOLISM

Key facts

Rebamipide is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2011. DrugCentral lists 1 molecular target, including Cckar. Recorded indications include Gastritis and Peptic ulcer.

• Molecular targets: Cckar (1 listed in DrugCentral).
• Indications: Gastritis and Peptic ulcer.
• ATC code: A02BX14 (Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)).
• Molecular formula: C19H15ClN2O4; molecular weight 370.79 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Gastritis
• Peptic ulcer

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Cholecystokinin receptor type A	Cckar	agonist	IC50 4.40

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2011-09-26	PMDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
A02BX14	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR ACID RELATED DISORDERS › DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) › Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Interstitial lung disease	605.1
Hepatic function abnormal	581.5
Platelet count decreased	382.9
Drug eruption	207.5
Cerebral infarction	192.8
Drug ineffective	188.8
Fatigue	188.6
Renal impairment	171.7
Malignant neoplasm progression	166.4
White blood cell count decreased	165.8
Neutrophil count decreased	162.2
Pyrexia	151.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Rebamipide is on its molecule page.

• Molecular formula: C₁₉H₁₅ClN₂O₄
• Molecular weight: 370.79 g/mol
• CAS number: 90098-04-7
• InChIKey: ALLWOAVDORUJLA-UHFFFAOYSA-N
• PubChem CID: 5042

OC(=O)C(CC1=CC(=O)NC2=CC=CC=C12)NC(=O)C1=CC=C(Cl)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Rebamipide used for?

DrugCentral lists the following indications for Rebamipide: Gastritis and Peptic ulcer.

How does Rebamipide work?

Its molecular targets in DrugCentral include Cckar (agonist).

When was Rebamipide first approved?

Rebamipide was first approved by the PMDA in 2011.

What is the chemical formula of Rebamipide?

Rebamipide has the molecular formula C19H15ClN2O4 and a molecular weight of 370.79 g/mol.

Sources

• DrugCentral drug card 2360 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1697771 — compound record and bioactivity
• PubChem CID 5042 — chemical identifiers
• DrugBank DB11656 — drug record
• FDA UNII LR583V32ZR — substance identity
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.