Tegafur

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Key facts

Tegafur is a drug catalogued in DrugCentral. It was first approved by the PMDA in 1999. Recorded indications include HER2-negative breast cancer, Hormone receptor pozitive breast cancer and Malignant tumor of stomach.

• Indications: HER2-negative breast cancer, Hormone receptor pozitive breast cancer and Malignant tumor of stomach.
• ATC code: L01BC03 (Pyrimidine analogues).
• Molecular formula: C8H9FN2O3; molecular weight 200.17 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• HER2-negative breast cancer
• Hormone receptor pozitive breast cancer
• Malignant tumor of stomach

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2011-03-14	EMA	—	Nordic Group BV
1999-03-01	PMDA	—	Taiho Pharmaceutical Co, Ltd

ATC classification

ATC code	Therapeutic hierarchy
L01BC03	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › ANTIMETABOLITES › Pyrimidine analogues
L01BC53	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › ANTIMETABOLITES › Pyrimidine analogues

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Myelosuppression	103.1
Bone marrow failure	78.6
Disease progression	54.4

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Tegafur is on its molecule page.

• Molecular formula: C₈H₉FN₂O₃
• Molecular weight: 200.17 g/mol
• CAS number: —
• InChIKey: WFWLQNSHRPWKFK-UHFFFAOYSA-N
• PubChem CID: 5386

FC1=CN(C2CCCO2)C(=O)NC1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Tegafur used for?

DrugCentral lists the following indications for Tegafur: HER2-negative breast cancer, Hormone receptor pozitive breast cancer and Malignant tumor of stomach.

When was Tegafur first approved?

Tegafur was first approved by the PMDA in 1999.

What is the chemical formula of Tegafur?

Tegafur has the molecular formula C8H9FN2O3 and a molecular weight of 200.17 g/mol.

Sources

• DrugCentral drug card 4398 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL20883 — compound record and bioactivity
• PubChem CID 5386 — chemical identifiers
• DrugBank DB09256 — drug record
• FDA UNII 1548R74NSZ — substance identity
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.