Trimethobenzamide

Antiemetic — RESPIRATORY SYSTEM

Key facts

Trimethobenzamide is an ofp drug in the Antiemetic class catalogued in DrugCentral. It was first approved by the FDA in 1974. Recorded indications include Nausea, Nausea and vomiting and Vomiting.

• Approval status: ofp (first approved 1974 by the FDA).
• Drug class: Antiemetic.
• Indications: Nausea, Nausea and vomiting and Vomiting.
• ATC code: R06AA10 (Aminoalkyl ethers).
• Molecular formula: C21H28N2O5; molecular weight 388.46 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Nausea
• Nausea and vomiting
• Vomiting

Contraindications (7)

• Bleeding hemorrhoids
• Dehydration
• Disorder of electrolytes
• Disorder of mucous membrane
• Encephalitis
• Fever greater than 100.4 Fahrenheit
• Kidney disease

Mechanism & targets

• Established pharmacologic class: Antiemetic

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1974-07-12	FDA	—	PAR STERILE PRODUCTS

ATC classification

ATC code	Therapeutic hierarchy
R06AA10	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Aminoalkyl ethers

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Nausea	53.1
Drug hypersensitivity	53.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Trimethobenzamide is on its molecule page.

• Molecular formula: C₂₁H₂₈N₂O₅
• Molecular weight: 388.46 g/mol
• CAS number: 138-56-7
• InChIKey: FEZBIKUBAYAZIU-UHFFFAOYSA-N
• PubChem CID: 5577

COC1=CC(=CC(OC)=C1OC)C(=O)NCC1=CC=C(OCCN(C)C)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Trimethobenzamide used for?

DrugCentral lists the following indications for Trimethobenzamide: Nausea, Nausea and vomiting and Vomiting.

When was Trimethobenzamide first approved?

Trimethobenzamide was first approved by the FDA in 1974.

What drug class does Trimethobenzamide belong to?

Trimethobenzamide is in the Antiemetic class.

What is the chemical formula of Trimethobenzamide?

Trimethobenzamide has the molecular formula C21H28N2O5 and a molecular weight of 388.46 g/mol.

Sources

• DrugCentral drug card 2754 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200887 — compound record and bioactivity
• PubChem CID 5577 — chemical identifiers
• DrugBank DB00662 — drug record
• FDA UNII W2X096QY97 — substance identity
• DailyMed: FDA labels for Trimethobenzamide — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.