Doxylamine

Antihistamine — RESPIRATORY SYSTEM

Key facts

Doxylamine is an ofp drug in the Antihistamine class catalogued in DrugCentral. It was first approved by the FDA in 1948. Its mechanism of action is classified as Histamine Receptor Antagonists. DrugCentral lists 1 molecular target, including HRH1. Recorded indications include Allergic conjunctivitis, Allergic rhinitis, Common cold and Dermatographic urticaria.

• Approval status: ofp (first approved 1948 by the FDA).
• Drug class: Antihistamine.
• Mechanism of action: Histamine Receptor Antagonists.
• Molecular targets: HRH1 (1 listed in DrugCentral).
• Indications: Allergic conjunctivitis, Allergic rhinitis, Common cold, Dermatographic urticaria and Influenza-like symptoms and others.
• ATC code: R06AA09 (Aminoalkyl ethers).
• Molecular formula: C17H22N2O; molecular weight 270.38 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (12)

• Allergic conjunctivitis
• Allergic rhinitis
• Common cold
• Dermatographic urticaria
• Influenza-like symptoms
• Itching of skin
• Nasal congestion
• Nasal discharge
• Seasonal allergic rhinitis
• Sneezing
• Urticaria
• Vasomotor rhinitis

Off-label uses (1)

• Morning sickness

Contraindications (28)

• Acidosis
• Acute hepatitis
• Acute pancreatitis
• Alcoholism
• Angle-closure glaucoma
• Arterial thrombosis
• Arteriosclerotic vascular disease
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Bradycardia
• Chronic heart failure
• Chronic idiopathic constipation
• Coronary arteriosclerosis
• Diabetes mellitus
• Disease of liver
• Disorder of coronary artery
• Hepatic failure
• Hypertensive disorder
• Hypertensive urgency
• Hyperthyroidism
• Hypoxia
• Myocardial infarction
• Ocular hypertension
• Partial atrioventricular block
• Peptic ulcer
• Poisoning by acetaminophen
• Retention of urine
• Ventricular tachycardia

Mechanism & targets

• Mechanism of action (MoA): Histamine Receptor Antagonists
• Established pharmacologic class: Antihistamine

Molecular targets (1)

Target	Gene	Action	Activity
Histamine H1 receptor	HRH1	antagonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1948-04-07	FDA	—	SANOFI AVENTIS US

ATC classification

ATC code	Therapeutic hierarchy
R06AA09	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Aminoalkyl ethers
R06AA59	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Aminoalkyl ethers

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Toxicity to various agents	7958.0
Completed suicide	4902.1
Exposure to toxic agent	3116.1
Intentional overdose	2825.7
Overdose	2797.6
Acute hepatic failure	2623.2
Infusion related reaction	1704.8
Blood pressure fluctuation	1360.6
Hepatic cytolysis	1154.7
Suicide attempt	1048.5
Intentional product misuse	897.2
Intentional product use issue	871.7

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Doxylamine is on its molecule page.

• Molecular formula: C₁₇H₂₂N₂O
• Molecular weight: 270.38 g/mol
• CAS number: 469-21-6
• InChIKey: HCFDWZZGGLSKEP-UHFFFAOYSA-N
• PubChem CID: 3162

CN(C)CCOC(C)(C1=CC=CC=C1)C1=NC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Doxylamine used for?

DrugCentral lists the following indications for Doxylamine: Allergic conjunctivitis, Allergic rhinitis, Common cold, Dermatographic urticaria, Influenza-like symptoms, Itching of skin, Nasal congestion and Nasal discharge and others.

How does Doxylamine work?

Doxylamine is classified as Histamine Receptor Antagonists; its molecular targets in DrugCentral include HRH1 (antagonist).

When was Doxylamine first approved?

Doxylamine was first approved by the FDA in 1948.

What drug class does Doxylamine belong to?

Doxylamine is in the Antihistamine class.

What is the chemical formula of Doxylamine?

Doxylamine has the molecular formula C17H22N2O and a molecular weight of 270.38 g/mol.

Sources

• DrugCentral drug card 962 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1004 — compound record and bioactivity
• PubChem CID 3162 — chemical identifiers
• DrugBank DB00366 — drug record
• FDA UNII 95QB77JKPL — substance identity
• DailyMed: FDA labels for Doxylamine — current prescribing information (label search)
• UniProt P35367 (HRH1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.