Bromazine

RESPIRATORY SYSTEM

Key facts

Bromazine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1954. DrugCentral lists 1 molecular target, including HRH1. Recorded indications include Common cold, Cough, Nasal congestion and Nasal discharge.

• Approval status: ofm (first approved 1954 by the FDA).
• Molecular targets: HRH1 (1 listed in DrugCentral).
• Indications: Common cold, Cough, Nasal congestion and Nasal discharge.
• ATC code: R06AA01 (Aminoalkyl ethers).
• Molecular formula: C17H20BrNO; molecular weight 334.26 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Common cold
• Cough
• Nasal congestion
• Nasal discharge

Contraindications (29)

• Acute abdominal pain
• Acute exacerbation of asthma
• Benign intracranial hypertension
• Benign prostatic hyperplasia
• Bradycardia
• Central nervous system depression
• Chronic disease of respiratory system
• Conduction disorder of the heart
• Decreased respiratory function
• Dependent drug abuse
• Disease of liver
• Disorder of gallbladder
• Drug AND/OR toxin-induced diarrhea
• Dysfunction of sphincter of Oddi
• Epilepsy
• Hypothyroidism
• Inflammatory bowel disease
• Injury of head
• Kidney disease
• Lesion of brain
• Low blood pressure
• Mood swings
• Operation on gastrointestinal tract
• Primary adrenocortical insufficiency
• Procedure on urinary system
• Pseudomembranous enterocolitis
• Substance abuse
• Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant
• Urethral stricture

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Histamine H1 receptor	HRH1	antagonist	Ki 8.89

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1954-04-28	FDA	—	FOREST LABS

ATC classification

ATC code	Therapeutic hierarchy
R06AA01	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Aminoalkyl ethers

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Bromazine is on its molecule page.

• Molecular formula: C₁₇H₂₀BrNO
• Molecular weight: 334.26 g/mol
• CAS number: 118-23-0
• InChIKey: NUNIWXHYABYXKF-UHFFFAOYSA-N
• PubChem CID: 2444

CN(C)CCOC(C1=CC=CC=C1)C1=CC=C(Br)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Bromazine used for?

DrugCentral lists the following indications for Bromazine: Common cold, Cough, Nasal congestion and Nasal discharge.

How does Bromazine work?

Its molecular targets in DrugCentral include HRH1 (antagonist).

When was Bromazine first approved?

Bromazine was first approved by the FDA in 1954.

What is the chemical formula of Bromazine?

Bromazine has the molecular formula C17H20BrNO and a molecular weight of 334.26 g/mol.

Sources

• DrugCentral drug card 404 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200967 — compound record and bioactivity
• PubChem CID 2444 — chemical identifiers
• DrugBank DB01237 — drug record
• FDA UNII 5A6HSK9TDT — substance identity
• DailyMed: FDA labels for Bromazine — current prescribing information (label search)
• UniProt P35367 (HRH1) — target protein

How this page is built: methodology · editorial policy & corrections.